In vivo evaluation of urokinase-loaded hollow nanogels for sonothrombolysis on suture embolization-induced acute ischemic stroke rat model.

Teng, Yuming; Jin, Haiqiang; Nan, Ding; Li, Mengnan; Fan, Chenghe; Liu, Yuanyuan; Lv, Pu; Cui, Wei; Sun, Yongan; Hao, Hongjun; Qu, Xiaozhong; Yang, Zhenzhong; Huang, Yining

In vivo evaluation of urokinase-loaded hollow nanogels for sonothrombolysis on suture embolization-induced acute ischemic stroke rat model.

Teng, Yuming; Jin, Haiqiang; Nan, Ding; Li, Mengnan; Fan, Chenghe; Liu, Yuanyuan; Lv, Pu; Cui, Wei; Sun, Yongan; Hao, Hongjun; Qu, Xiaozhong; Yang, Zhenzhong; Huang, Yining.

Afiliação

Teng Y; Department of Neurology, Peking University First Hospital, Beijing 100034, China.
Jin H; Department of Neurology, Peking University First Hospital, Beijing 100034, China.
Nan D; Department of Neurology, Peking University First Hospital, Beijing 100034, China.
Li M; State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Fan C; Department of Neurology, Peking University First Hospital, Beijing 100034, China.
Liu Y; Department of Neurology, Peking University First Hospital, Beijing 100034, China.
Lv P; Department of Neurology, Peking University First Hospital, Beijing 100034, China.
Cui W; Department of Neurology, Peking University First Hospital, Beijing 100034, China.
Sun Y; Department of Neurology, Peking University First Hospital, Beijing 100034, China.
Hao H; Department of Neurology, Peking University First Hospital, Beijing 100034, China.
Qu X; College of Materials and Opto-Electronic Technology, University of Chinese Academy of Sciences, Beijing 100049, China.
Yang Z; State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Huang Y; Department of Neurology, Peking University First Hospital, Beijing 100034, China.

Bioact Mater ; 3(1): 102-109, 2018 Mar.

Article em En | MEDLINE | ID: mdl-29744447

Palavras-chave

BBB, blood-brain barrier; CCA, common carotid artery; EB, evens blue; ELIP, echogenic liposomes; HT, hemorrhagic transformation; Hb, hemoglobin; Hollow nanogel; In vivo evaluation; MCA, middle cerebral artery; MCAO, middle cerebral artery occlusion; MRI, magnetic resonance imaging; SD, Sprague-Dawley; TCD, Transcranial Doppler; TTC, 2,3,5-triphenyltetrazolium chloride; Thrombolysis; UK+US, ultrasound and free urokinase; UK, urokinase; US, ultrasound; Ultrasound responsive; Urokinase delivery; nUK+US, ultrasound and uPA-loaded nanogels; nUK, uPA-loaded nanogels

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2018 Tipo de documento: Article