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[Non-contacting photoacoustic tomography in biological samples].
Wang, Cheng; Cai, Gan; Dong, Xiaona; Yang, Jing; Weng, Xiaofu; Wei, Xunbin.
Afiliação
  • Wang C; Institute of Biomedical Optics & Optometry, School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, P.R.China.shhwangcheng@163.com.
  • Cai G; Institute of Biomedical Optics & Optometry, School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, P.R.China.
  • Dong X; Institute of Biomedical Optics & Optometry, School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, P.R.China.
  • Yang J; Institute of Biomedical Optics & Optometry, School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, P.R.China.
  • Weng X; School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, P.R.China.
  • Wei X; School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, P.R.China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi ; 34(3): 439-444, 2017 Jun 01.
Article em Zh | MEDLINE | ID: mdl-29745511
ABSTRACT
In photoacoustic imaging the ultrasonic signals are usually detected by contacting transducers. For some applications, contact with the tissue should be avoided, e.g. in those of brain functional imaging. As alternatives to contacting transducers interferometric techniques can be used to acquire photoacoustic signals remotely. Here, a system for non-contact photoacoustic tomography imaging (NCPAT) has been established. This approach enables NCPAT not to exceed laser exposure safety limits. The stimulated source of NCPAT utilized a laser with center wavelength of 532 nm and output intensity of 17.5 mJ/cm 2, and a laser heterodyne interferometry was used to receive the photoacoustic signals. The NCPAT was used to implement on a rotational imaging geometry for photoacoustic tomography with a real-tissue phantom. The photoacoustic imaging was obtained by applying a reconstruction algorithm to the data acquired for NCPAT. Experiments results showed that the NCPAT system with detection 15 dB bandwidth of 2.25 MHz could resolve spherical optical inclusions with dimension of 500 µm and multi-layered structure with optical contrast in strongly scattering medium. The method could expand the scope of photoacoustic and ultrasonic technology to in-vivo biomedical applications where contact is impractical.
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Texto completo: 1 Base de dados: MEDLINE Idioma: Zh Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: Zh Ano de publicação: 2017 Tipo de documento: Article