Rac1 muscle knockout exacerbates the detrimental effect of high-fat diet on insulin-stimulated muscle glucose uptake independently of Akt.

Raun, Steffen H; Ali, Mona; Kjøbsted, Rasmus; Møller, Lisbeth L V; Federspiel, Morten A; Richter, Erik A; Jensen, Thomas E; Sylow, Lykke

Raun, Steffen H; Ali, Mona; Kjøbsted, Rasmus; Møller, Lisbeth L V; Federspiel, Morten A; Richter, Erik A; Jensen, Thomas E; Sylow, Lykke.

Afiliação

Raun SH; Molecular Physiology Group, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Universitetsparken 13, Copenhagen, 2100, Denmark.
Ali M; Molecular Physiology Group, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Universitetsparken 13, Copenhagen, 2100, Denmark.
Kjøbsted R; Molecular Physiology Group, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Universitetsparken 13, Copenhagen, 2100, Denmark.
Møller LLV; Molecular Physiology Group, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Universitetsparken 13, Copenhagen, 2100, Denmark.
Federspiel MA; Cell Biology and Physiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Richter EA; Molecular Physiology Group, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Universitetsparken 13, Copenhagen, 2100, Denmark.
Jensen TE; Molecular Physiology Group, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Universitetsparken 13, Copenhagen, 2100, Denmark.
Sylow L; Molecular Physiology Group, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Universitetsparken 13, Copenhagen, 2100, Denmark.

J Physiol ; 596(12): 2283-2299, 2018 06.

Article em En | MEDLINE | ID: mdl-29749029

Assuntos

Dieta Hiperlipídica/efeitos adversos; Glucose/metabolismo; Resistência à Insulina; Músculo Esquelético/patologia; Neuropeptídeos/metabolismo; Proteínas rac1 de Ligação ao GTP/metabolismo; Animais; Transporte Biológico; Feminino; Hipoglicemiantes/farmacologia; Insulina/metabolismo; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Músculo Esquelético/efeitos dos fármacos; Músculo Esquelético/metabolismo; Proteínas Proto-Oncogênicas c-akt/genética; Proteínas Proto-Oncogênicas c-akt/metabolismo; Transdução de Sinais

Palavras-chave

Rac1; adipose tissue; diet-induced obesity; glucose homeostasis; glucose uptake; muscle

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neuropeptídeos / Resistência à Insulina / Músculo Esquelético / Proteínas rac1 de Ligação ao GTP / Dieta Hiperlipídica / Glucose Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google