Predictors of bone maturation, growth rate and adult height in children with central precocious puberty treated with depot leuprolide acetate.
J Pediatr Endocrinol Metab
; 31(6): 655-663, 2018 Jun 27.
Article
em En
| MEDLINE
| ID: mdl-29750651
ABSTRACT
BACKGROUND:
Children with central precocious puberty (CPP) are treated with gonadotropin-releasing hormone agonists (GnRHa) to suppress puberty. Optimizing treatment outcomes continues to be studied. The relationships between growth, rate of bone maturation (bone age/chronological age [ΔBA/ΔCA]), luteinizing hormone (LH), predicted adult stature (PAS), as well as variables influencing these outcomes, were studied in children treated with depot leuprolide (LA Depot)Methods:
Subjects (64 girls, seven boys) with CPP received LA Depot every 3 months for up to 42 months. Multivariate regression analyses were conducted to examine the predictors affecting ΔBA/ΔCA, PAS and growth rate.RESULTS:
Ninety percent of subjects (18 of 20) were suppressed (LH levels <4 IU/L) at 42 months. Over 42 months, the mean growth rate declined 2 cm/year, the mean BA/CA ratio decreased 0.21 and PAS increased 8.90 cm for girls (n=64). PAS improved to mid-parental height (MPH) in 46.2% of children by 30 months of treatment. Regression analysis showed that only the Body Mass Index Standardized Score (BMI SDS) was significantly associated (ß+0.378 and +0.367, p≤0.05) with growth rate. For PAS, significant correlations were with MPH (ß+0.808 and +0.791, p<0.001) and ΔBA/ΔCA (ß+0.808 and +0.791, p<0.001). For ΔBA/ΔCA, a significant association was found only with BA at onset of treatment (ß-0.098 and -0.103, p≤0.05). Peak-stimulated or basal LH showed no significant influence on growth rate, ΔBA/ΔCA or PAS.CONCLUSIONS:
Growth rate and bone maturation rate normalized on treatment with LA Depot. LH levels were not significantly correlated with growth rate, ΔBA/ΔCA or PAS, suggesting that suppression was adequate and variations in gonadotropin levels were below the threshold affecting outcomes.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Puberdade Precoce
/
Estatura
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Desenvolvimento Ósseo
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Biomarcadores
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Desenvolvimento Infantil
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Leuprolida
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article