[The significance of lymphocyte to monocyte ratio in peripheral blood of patients with benign and malignant laryngeal lesions].

Objective:The aim of this study is to investigate the value of preoperative peripheral blood lymphocyte to monocyte ratio (LMR) in differentiating laryngeal squamous cell carcinoma (LSCC), laryngeal precancerous lesions (LPL) and laryngeal benign lesions (LBL). Method:Four hundred and five cases of laryngeal lesions diagnosed by pathology (154 cases of LSCC, 83 cases of LPL and 168 cases of LBL) were collected. LSCC group was further divided into T1 group, T2 group and T3-4 group based on T stage. The levels of neutrophils, lymphocytes, monocytes, hemoglobin, platelet and other blood indexes were measured, as well as compared the LMR, neutrophil to lymphocyte ratio (NLR) and other parameters in each group. Result:The LMR and NLR in LBL, LPL and LSCC groups was 4.88±1.65 and 4.61±1.59, 3.92±1.77 and 2.11±0.79, 2.08±0.77 and 2.63±1.69, respectively. The LMR in the LSCC group was significantly lower than those in the LBL and LPL group (P<0.01), whereas the NLR was significantly higher than those in LBL and LPL group (P<0.05). Either LMR or NLR between the LBL and LPL group was not statistically different (P>0.05). The LMR of patients with local advanced (T3-4) stage in the LSCC group was lower than that in the early or medium stage (T1-2), while the NLR was higher and the difference was statistically significant (P<0.05). There was no significant difference in platelet, white blood cell and neutrophil count between LBL, LPL and LSCC (P>0.05). Conclusion:We, for the first time, compared LMR in different laryngeal lesions and found that LMR and NLR as a systemic inflammatory index have a certain reference value for to differentiate LSCC from LPL and LBL.