Post-partum psychosis in adult GM2 gangliosidosis. A case report.
Br J Psychiatry
; 153: 387-9, 1988 Sep.
Article
em En
| MEDLINE
| ID: mdl-2977954
ABSTRACT
Adult hexosaminidase A deficiency is a form of GM2 gangliosidosis with autosomal recessive inheritance. Only 35 cases (mostly among Ashkenazic Jews) have been reported worldwide. Symptoms include, in a third of the cases, psychosis. A 27-year-old sufferer with no prior psychiatric history, developed a post-partum psychosis, with affective and hebephrenic components, 3 days following her first delivery. She responded to lithium within 10 days of initiating treatment; the full episode lasted 1 month. We conclude that lithium is the preferred treatment for psychosis in such adult patients, especially in light of possible long-term neurological deterioration caused by phenothiazines. Ashkenazic Jews with atypical neurological syndromes presenting with psychosis should be tested for hexosaminidase A deficiency.
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Base de dados:
MEDLINE
Assunto principal:
Transtornos Psicóticos
/
Transtornos Puerperais
/
Gangliosidoses
Idioma:
En
Ano de publicação:
1988
Tipo de documento:
Article