Identification of TB-E12 as a novel FtsZ inhibitor with anti-tuberculosis activity.

Lin, Yuan; Zhang, Hongjuan; Zhu, Ningyu; Wang, Xia; Han, Yanxing; Chen, Minghua; Jiang, Jiandong; Si, Shuyi

Lin, Yuan; Zhang, Hongjuan; Zhu, Ningyu; Wang, Xia; Han, Yanxing; Chen, Minghua; Jiang, Jiandong; Si, Shuyi.

Afiliação

Lin Y; State Key Laboratory of Bioactive Substances and Function of Natural Medicine, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Zhang H; State Key Laboratory of Bioactive Substances and Function of Natural Medicine, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Zhu N; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Wang X; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Han Y; State Key Laboratory of Bioactive Substances and Function of Natural Medicine, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Chen M; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Jiang J; State Key Laboratory of Bioactive Substances and Function of Natural Medicine, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College
Si S; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address: sisyimb@hotmail.com.

Tuberculosis (Edinb) ; 110: 79-85, 2018 05.

Article em En | MEDLINE | ID: mdl-29779778

Assuntos

Antituberculosos/farmacologia; Proteínas de Bactérias/antagonistas & inibidores; Proteínas do Citoesqueleto/antagonistas & inibidores; Mycobacterium smegmatis/efeitos dos fármacos; Mycobacterium tuberculosis/efeitos dos fármacos; Proteínas de Bactérias/metabolismo; Proliferação de Células/efeitos dos fármacos; Proteínas do Citoesqueleto/metabolismo; Desenho de Fármacos; GTP Fosfo-Hidrolases/antagonistas & inibidores; GTP Fosfo-Hidrolases/metabolismo; Humanos; Testes de Sensibilidade Microbiana/métodos; Simulação de Acoplamento Molecular/métodos; Terapia de Alvo Molecular/métodos; Mutagênese Sítio-Dirigida; Mycobacterium smegmatis/genética; Mycobacterium smegmatis/crescimento & desenvolvimento; Mycobacterium smegmatis/metabolismo; Mycobacterium tuberculosis/genética; Mycobacterium tuberculosis/crescimento & desenvolvimento; Mycobacterium tuberculosis/metabolismo; Especificidade da Espécie

Palavras-chave

Anti-tuberculosis; FtsZ; Inhibitor

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Bactérias / Mycobacterium smegmatis / Proteínas do Citoesqueleto / Mycobacterium tuberculosis / Antituberculosos Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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