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The personalized Alzheimer's disease cortical thickness index predicts likely pathology and clinical progression in mild cognitive impairment.
Racine, Annie M; Brickhouse, Michael; Wolk, David A; Dickerson, Bradford C.
Afiliação
  • Racine AM; Aging Brain Center, Institute for Aging Research, Hebrew SeniorLife, Boston, MA, USA.
  • Brickhouse M; Harvard Medical School, Boston, MA, USA.
  • Wolk DA; Frontotemporal Disorders Unit, Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.
  • Dickerson BC; Frontotemporal Disorders Unit, Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Alzheimers Dement (Amst) ; 10: 301-310, 2018.
Article em En | MEDLINE | ID: mdl-29780874
ABSTRACT

INTRODUCTION:

An Alzheimer's disease (AD) biomarker adjusted for age-related brain changes should improve specificity for AD-related pathological burden.

METHODS:

We calculated a brain-age-adjusted "personalized AD cortical thickness index" (pADi) in mild cognitive impairment patients from the Alzheimer's Disease Neuroimaging Initiative. We performed receiver operating characteristic analysis for discrimination between patients with and without cerebrospinal fluid evidence of AD and logistic regression in an independent sample to determine if a dichotomized pADi predicted conversion to AD dementia.

RESULTS:

Receiver operating characteristic area under the curve was 0.69 and 0.72 in the two samples. Three empirical methods identified the same cut-point for pADi in the discovery sample. In the validation sample, 83% of pADi+ mild cognitive impairment patients were cerebrospinal fluid AD biomarker positive. pADi+ mild cognitive impairment patients (n = 63, 38%) were more likely to progress to AD dementia after 1 (odds ratio = 2.9) and 3 (odds ratio = 2.6) years.

DISCUSSION:

The pADi is a personalized, magnetic resonance imaging-derived AD biomarker that predicts progression to dementia.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2018 Tipo de documento: Article