Homoharringtonine regulates the alternative splicing of Bcl-x and caspase 9 through a protein phosphatase 1-dependent mechanism.

Sun, Qi; Li, Shiyue; Li, Junjun; Fu, Qiuxia; Wang, Zhongyuan; Li, Bo; Liu, Shan-Shan; Su, Zijie; Song, Jiaxing; Lu, Desheng

Sun, Qi; Li, Shiyue; Li, Junjun; Fu, Qiuxia; Wang, Zhongyuan; Li, Bo; Liu, Shan-Shan; Su, Zijie; Song, Jiaxing; Lu, Desheng.

Afiliação

Sun Q; Guangdong Key Laboratory for Genome Stability & Disease Prevention, Carson International Cancer Center, Department of Pharmacology, Shenzhen University Health Science Center, Shenzhen, 518060, Guangdong, China.
Li S; Guangdong Key Laboratory for Genome Stability & Disease Prevention, Carson International Cancer Center, Department of Pharmacology, Shenzhen University Health Science Center, Shenzhen, 518060, Guangdong, China.
Li J; Guangdong Key Laboratory for Genome Stability & Disease Prevention, Carson International Cancer Center, Department of Pharmacology, Shenzhen University Health Science Center, Shenzhen, 518060, Guangdong, China.
Fu Q; Guangdong Key Laboratory for Genome Stability & Disease Prevention, Carson International Cancer Center, Department of Pharmacology, Shenzhen University Health Science Center, Shenzhen, 518060, Guangdong, China.
Wang Z; Guangdong Key Laboratory for Genome Stability & Disease Prevention, Carson International Cancer Center, Department of Pharmacology, Shenzhen University Health Science Center, Shenzhen, 518060, Guangdong, China.
Li B; Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, 300072, China.
Liu SS; Guangdong Key Laboratory for Genome Stability & Disease Prevention, Carson International Cancer Center, Department of Pharmacology, Shenzhen University Health Science Center, Shenzhen, 518060, Guangdong, China.
Su Z; Guangdong Key Laboratory for Genome Stability & Disease Prevention, Carson International Cancer Center, Department of Pharmacology, Shenzhen University Health Science Center, Shenzhen, 518060, Guangdong, China.
Song J; Guangdong Key Laboratory for Genome Stability & Disease Prevention, Carson International Cancer Center, Department of Pharmacology, Shenzhen University Health Science Center, Shenzhen, 518060, Guangdong, China.
Lu D; Guangdong Key Laboratory for Genome Stability & Disease Prevention, Carson International Cancer Center, Department of Pharmacology, Shenzhen University Health Science Center, Shenzhen, 518060, Guangdong, China. delu@szu.edu.cn.

BMC Complement Altern Med ; 18(1): 164, 2018 May 22.

Article em En | MEDLINE | ID: mdl-29788973

Assuntos

Processamento Alternativo/efeitos dos fármacos; Caspase 9/metabolismo; Harringtoninas/farmacologia; Proteína Fosfatase 1/metabolismo; Proteína bcl-X/metabolismo; Animais; Apoptose/efeitos dos fármacos; Linhagem Celular Tumoral; Mepesuccinato de Omacetaxina; Humanos; Camundongos

Palavras-chave

Apoptosis; Bcl-x; Caspase 9; Homoharringtonine, Alternative splicing; Protein phosphatase 1

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Processamento Alternativo / Proteína bcl-X / Caspase 9 / Proteína Fosfatase 1 / Harringtoninas Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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