Your browser doesn't support javascript.
loading
Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models.
Ng, Samuel Y; Yoshida, Noriaki; Christie, Amanda L; Ghandi, Mahmoud; Dharia, Neekesh V; Dempster, Joshua; Murakami, Mark; Shigemori, Kay; Morrow, Sara N; Van Scoyk, Alexandria; Cordero, Nicolas A; Stevenson, Kristen E; Puligandla, Maneka; Haas, Brian; Lo, Christopher; Meyers, Robin; Gao, Galen; Cherniack, Andrew; Louissaint, Abner; Nardi, Valentina; Thorner, Aaron R; Long, Henry; Qiu, Xintao; Morgan, Elizabeth A; Dorfman, David M; Fiore, Danilo; Jang, Julie; Epstein, Alan L; Dogan, Ahmet; Zhang, Yanming; Horwitz, Steven M; Jacobsen, Eric D; Santiago, Solimar; Ren, Jian-Guo; Guerlavais, Vincent; Annis, D Allen; Aivado, Manuel; Saleh, Mansoor N; Mehta, Amitkumar; Tsherniak, Aviad; Root, David; Vazquez, Francisca; Hahn, William C; Inghirami, Giorgio; Aster, Jon C; Weinstock, David M; Koch, Raphael.
Afiliação
  • Ng SY; Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Ave, Boston, MA, 02215, USA.
  • Yoshida N; Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Ave, Boston, MA, 02215, USA.
  • Christie AL; Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Ave, Boston, MA, 02215, USA.
  • Ghandi M; Broad Institute of Harvard and MIT, 415 Main St, Cambridge, MA, 02142, USA.
  • Dharia NV; Broad Institute of Harvard and MIT, 415 Main St, Cambridge, MA, 02142, USA.
  • Dempster J; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, 450 Brookline Ave, Boston, MA, 02215, USA.
  • Murakami M; Harvard Medical School, 25 Shattuck Street, Boston, MA, 02115, USA.
  • Shigemori K; Broad Institute of Harvard and MIT, 415 Main St, Cambridge, MA, 02142, USA.
  • Morrow SN; Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Ave, Boston, MA, 02215, USA.
  • Van Scoyk A; Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Ave, Boston, MA, 02215, USA.
  • Cordero NA; Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Ave, Boston, MA, 02215, USA.
  • Stevenson KE; Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Ave, Boston, MA, 02215, USA.
  • Puligandla M; Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Ave, Boston, MA, 02215, USA.
  • Haas B; Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, 450 Brookline Ave, Boston, MA, 02215, USA.
  • Lo C; Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, 450 Brookline Ave, Boston, MA, 02215, USA.
  • Meyers R; Broad Institute of Harvard and MIT, 415 Main St, Cambridge, MA, 02142, USA.
  • Gao G; Broad Institute of Harvard and MIT, 415 Main St, Cambridge, MA, 02142, USA.
  • Cherniack A; Broad Institute of Harvard and MIT, 415 Main St, Cambridge, MA, 02142, USA.
  • Louissaint A; Broad Institute of Harvard and MIT, 415 Main St, Cambridge, MA, 02142, USA.
  • Nardi V; Broad Institute of Harvard and MIT, 415 Main St, Cambridge, MA, 02142, USA.
  • Thorner AR; Harvard Medical School, 25 Shattuck Street, Boston, MA, 02115, USA.
  • Long H; Department of Pathology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA.
  • Qiu X; Harvard Medical School, 25 Shattuck Street, Boston, MA, 02115, USA.
  • Morgan EA; Department of Pathology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA.
  • Dorfman DM; Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, 450 Brookline Ave, Boston, MA, 02215, USA.
  • Fiore D; Center for Functional Epigenetics, Dana-Farber Cancer Institute, 450 Brookline Ave, Boston, MA, 02215, USA.
  • Jang J; Center for Functional Epigenetics, Dana-Farber Cancer Institute, 450 Brookline Ave, Boston, MA, 02215, USA.
  • Epstein AL; Harvard Medical School, 25 Shattuck Street, Boston, MA, 02115, USA.
  • Dogan A; Department of Pathology, Brigham and Women's Hospital, 75 Francis St, Boston, MA, 02215, USA.
  • Zhang Y; Harvard Medical School, 25 Shattuck Street, Boston, MA, 02115, USA.
  • Horwitz SM; Department of Pathology, Brigham and Women's Hospital, 75 Francis St, Boston, MA, 02215, USA.
  • Jacobsen ED; Department of Pathology, Weill Cornell Medical College, 525 East 68th Street, New York, NY, 10065, USA.
  • Santiago S; Department of Pathology, Keck School of Medicine, University of Southern California, 1975 Zonal Ave, Los Angeles, CA, 90033, USA.
  • Ren JG; Department of Pathology, Keck School of Medicine, University of Southern California, 1975 Zonal Ave, Los Angeles, CA, 90033, USA.
  • Guerlavais V; Department of Pathology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.
  • Annis DA; Department of Pathology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.
  • Aivado M; Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.
  • Saleh MN; Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Ave, Boston, MA, 02215, USA.
  • Mehta A; Harvard Medical School, 25 Shattuck Street, Boston, MA, 02115, USA.
  • Tsherniak A; Aileron Therapeutics Inc, 281 Albany Street, Cambridge, MA, 02139, USA.
  • Root D; Aileron Therapeutics Inc, 281 Albany Street, Cambridge, MA, 02139, USA.
  • Vazquez F; Aileron Therapeutics Inc, 281 Albany Street, Cambridge, MA, 02139, USA.
  • Hahn WC; Aileron Therapeutics Inc, 281 Albany Street, Cambridge, MA, 02139, USA.
  • Inghirami G; Aileron Therapeutics Inc, 281 Albany Street, Cambridge, MA, 02139, USA.
  • Aster JC; University of Alabama-Birmingham Comprehensive Cancer Center, 1824 6th Avenue South, Birmingham, AL, 3523, USA.
  • Weinstock DM; University of Alabama-Birmingham Comprehensive Cancer Center, 1824 6th Avenue South, Birmingham, AL, 3523, USA.
  • Koch R; Broad Institute of Harvard and MIT, 415 Main St, Cambridge, MA, 02142, USA.
Nat Commun ; 9(1): 2024, 2018 05 22.
Article em En | MEDLINE | ID: mdl-29789628
Assuntos
Antineoplásicos/farmacologia; Regulação Neoplásica da Expressão Gênica; Linfoma Extranodal de Células T-NK/tratamento farmacológico; Linfoma de Células T/tratamento farmacológico; Proteínas Nucleares/genética; Peptídeos/farmacologia; Proteínas Proto-Oncogênicas c-mdm2/genética; Proteínas Proto-Oncogênicas/genética; Proteína Supressora de Tumor p53/genética; Animais; Proteínas de Ciclo Celular; Depsipeptídeos/farmacologia; Avaliação Pré-Clínica de Medicamentos; Humanos; Fator de Transcrição Ikaros/antagonistas & inibidores; Fator de Transcrição Ikaros/genética; Fator de Transcrição Ikaros/metabolismo; Imidazolinas/farmacologia; Janus Quinase 2/antagonistas & inibidores; Janus Quinase 2/genética; Janus Quinase 2/metabolismo; Linfoma Extranodal de Células T-NK/genética; Linfoma Extranodal de Células T-NK/metabolismo; Linfoma Extranodal de Células T-NK/patologia; Linfoma de Células T/genética; Linfoma de Células T/metabolismo; Linfoma de Células T/patologia; Camundongos; Proteínas Nucleares/antagonistas & inibidores; Proteínas Nucleares/metabolismo; Ligação Proteica/efeitos dos fármacos; Proteínas Proto-Oncogênicas/antagonistas & inibidores; Proteínas Proto-Oncogênicas/metabolismo; Proteínas Proto-Oncogênicas c-mdm2/antagonistas & inibidores; Proteínas Proto-Oncogênicas c-mdm2/metabolismo; Indução de Remissão; Transdução de Sinais; Proteína Supressora de Tumor p53/antagonistas & inibidores; Proteína Supressora de Tumor p53/metabolismo; Sequenciamento do Exoma; Ensaios Antitumorais Modelo de Xenoenxerto
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos / Proteínas Nucleares / Regulação Neoplásica da Expressão Gênica / Linfoma de Células T / Proteína Supressora de Tumor p53 / Proteínas Proto-Oncogênicas / Proteínas Proto-Oncogênicas c-mdm2 / Linfoma Extranodal de Células T-NK / Antineoplásicos Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos / Proteínas Nucleares / Regulação Neoplásica da Expressão Gênica / Linfoma de Células T / Proteína Supressora de Tumor p53 / Proteínas Proto-Oncogênicas / Proteínas Proto-Oncogênicas c-mdm2 / Linfoma Extranodal de Células T-NK / Antineoplásicos Idioma: En Ano de publicação: 2018 Tipo de documento: Article