Chemoproteomics of matrix metalloproteases in a model of cartilage degeneration suggests functional biomarkers associated with posttraumatic osteoarthritis.

Ravindra, Kodihalli C; Ahrens, Caroline C; Wang, Yang; Ramseier, Julie Y; Wishnok, John S; Griffith, Linda G; Grodzinsky, Alan J; Tannenbaum, Steven R

Ravindra, Kodihalli C; Ahrens, Caroline C; Wang, Yang; Ramseier, Julie Y; Wishnok, John S; Griffith, Linda G; Grodzinsky, Alan J; Tannenbaum, Steven R.

Afiliação

Ravindra KC; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139.
Ahrens CC; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139.
Wang Y; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139.
Ramseier JY; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139.
Wishnok JS; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139.
Griffith LG; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139; Center for Gynepathology Research, Massachusetts Institute of Technology, Cambridge,
Grodzinsky AJ; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139; Department of Electrical Engineering and Computer Science, Massachusetts Institute
Tannenbaum SR; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139. Electronic address: srt@mit.edu.

J Biol Chem ; 293(29): 11459-11469, 2018 07 20.

Article em En | MEDLINE | ID: mdl-29794029

Assuntos

Cartilagem Articular/patologia; Metaloproteinases da Matriz/análise; Osteoartrite/patologia; Animais; Cartilagem Articular/metabolismo; Bovinos; Ativação Enzimática; Interleucina-1alfa/metabolismo; Metaloproteinases da Matriz/metabolismo; Osteoartrite/metabolismo; Proteoma/análise; Proteoma/metabolismo; Técnicas de Cultura de Tecidos

Palavras-chave

ADAMTS; matrix metalloproteinase (MMP); osteoarthritis; peptidase; protein engineering

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Osteoartrite / Cartilagem Articular / Metaloproteinases da Matriz Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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