Duhuo Jisheng Decoction inhibits SDF-1-induced inflammation and matrix degradation in human degenerative nucleus pulposus cells in vitro through the CXCR4/NF-&#954;B pathway.

Liu, Zong-Chao; Wang, Zhen-Long; Huang, Chen-Yi; Fu, Zhi-Jiang; Liu, Yong; Wei, Zhang-Chao; Liu, Shi-Gui; Ma, Chuan; Shen, Jie-Liang; Duan, Dayue Darrel

Duhuo Jisheng Decoction inhibits SDF-1-induced inflammation and matrix degradation in human degenerative nucleus pulposus cells in vitro through the CXCR4/NF-κB pathway.

Liu, Zong-Chao; Wang, Zhen-Long; Huang, Chen-Yi; Fu, Zhi-Jiang; Liu, Yong; Wei, Zhang-Chao; Liu, Shi-Gui; Ma, Chuan; Shen, Jie-Liang; Duan, Dayue Darrel.

Afiliação

Liu ZC; Department of Orthopedic Surgery, the Traditional Chinese Medicine Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.
Wang ZL; Department of Orthopedic Surgery, the Traditional Chinese Medicine Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.
Huang CY; Department of Orthopedic Surgery, the Traditional Chinese Medicine Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.
Fu ZJ; Department of Orthopedic Surgery, the Traditional Chinese Medicine Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.
Liu Y; Department of Orthopedic Surgery, the Traditional Chinese Medicine Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.
Wei ZC; Department of Orthopedic Surgery, the Traditional Chinese Medicine Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.
Liu SG; Department of Orthopedic Surgery, the Traditional Chinese Medicine Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.
Ma C; Department of Orthopedic Surgery, the Traditional Chinese Medicine Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.
Shen JL; Department of Orthopedic Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Duan DD; Center for Phenomics of Traditional Chinese Medicine, Southwest Medical University, Luzhou 646000, China.

Acta Pharmacol Sin ; 39(6): 912-922, 2018 Jun.

Article em En | MEDLINE | ID: mdl-29795361

Assuntos

Anti-Inflamatórios/farmacologia; Quimiocina CXCL12/farmacologia; Medicamentos de Ervas Chinesas/farmacologia; Matriz Extracelular/metabolismo; Degeneração do Disco Intervertebral/tratamento farmacológico; Dor Lombar/tratamento farmacológico; Vértebras Lombares/efeitos dos fármacos; NF-kappa B/metabolismo; Núcleo Pulposo/efeitos dos fármacos; Receptores CXCR4/metabolismo; Adulto; Idoso; Estudos de Casos e Controles; Células Cultivadas; Citocinas/metabolismo; Relação Dose-Resposta a Droga; Feminino; Humanos; Mediadores da Inflamação/metabolismo; Degeneração do Disco Intervertebral/imunologia; Degeneração do Disco Intervertebral/metabolismo; Degeneração do Disco Intervertebral/patologia; Dor Lombar/imunologia; Dor Lombar/metabolismo; Dor Lombar/patologia; Vértebras Lombares/imunologia; Vértebras Lombares/metabolismo; Vértebras Lombares/patologia; Masculino; Metaloproteinases da Matriz Secretadas/metabolismo; Pessoa de Meia-Idade; Núcleo Pulposo/imunologia; Núcleo Pulposo/metabolismo; Núcleo Pulposo/patologia; Receptores CXCR4/genética; Transdução de Sinais/efeitos dos fármacos; Fator de Transcrição RelA/metabolismo; Adulto Jovem

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Medicamentos de Ervas Chinesas / NF-kappa B / Dor Lombar / Receptores CXCR4 / Matriz Extracelular / Quimiocina CXCL12 / Degeneração do Disco Intervertebral / Núcleo Pulposo / Vértebras Lombares / Anti-Inflamatórios Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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