CGRP Receptor Biology: Is There More Than One Receptor?
Handb Exp Pharmacol
; 255: 13-22, 2019.
Article
em En
| MEDLINE
| ID: mdl-29797087
ABSTRACT
Calcitonin gene-related peptide (CGRP) has many reported pharmacological actions. Can a single receptor explain all of these? This chapter outlines the molecular nature of reported CGRP binding proteins and their pharmacology. Consideration of whether CGRP has only one or has more receptors is important because of the key role that this peptide plays in migraine. It is widely thought that the calcitonin receptor-like receptor together with receptor activity-modifying protein 1 (RAMP1) is the only relevant receptor for CGRP. However, some closely related receptors also have high affinity for CGRP and it is still plausible that these play a role in CGRP biology, and in migraine. The calcitonin receptor/RAMP1 complex, which is currently called the AMY1 receptor, seems to be the most likely candidate but more investigation is needed to determine its role.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Receptores de Peptídeo Relacionado com o Gene de Calcitonina
/
Transtornos de Enxaqueca
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article