[Expression and significance of serum insulin-like growth factor-1 in patients with obstructive sleep apnea hypopnea syndrome].
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
; 32(7): 481-484, 2018 Apr.
Article
em Zh
| MEDLINE
| ID: mdl-29798073
ABSTRACT
Objective:
To investigate the expression and significance of serum insulinîlike growth factor-1(IGF-1) in adult patients with obstructive sleep apnea hypopnea syndrome(OSAHS).Method:
One hundred and seven patients of OSAHS diagnosed with PSG were included in the observation groupï¼which were divided into heavy, medium and light group according to AHI.Fifty case of healthy people without OSAHS were included in control group.Serum IGF-1 were measured by ELISA. Thirty patients of heavy OSAHS received surgery and CPAP treatment for three months,and were retested the levels of IGF-1 and PSG six months later.Result:
â With the increase of OSAHS severity, the levels of serum IGF-1 were gradually decreased (F=37.732,P<0.01). There was no significant difference between mild group and healthy people (P>0.05), while there was significant differences between the remaining groups (P<0.01). â¡Serum IGF-1 level has no correlation with BMI and age in OSAHS patients(P>0.05), and negatively correlated with LSaO2,and positively correlated with AHI (P<0.01). â¢Serum IGF-1 levelï¼»(46.56±3.74)µg/Lï¼½ increased slightly compared with those before treatmentï¼»(42.79±4.87ï¼µg/Lï¼½ in 30 severe patients after treatment with 3 months CPAP and regimen (P<0.01). Serum IGF-1 levelï¼»(56.61±5.46)µg/Lï¼½ increased significantly after treatment for six months; AHI level (18.72±7.36) was significantly lower than that before treatment (48.77±10.51), and LSaO2ï¼»(87.42±8.61)%ï¼½ increased significantly than that before treatmentï¼»(68.33±10.24)%ï¼½.Conclusion:
OSAHS patients with decreased serum IGF-1 level may be associated with concurrent insulin resistance. Surgery combined with more than half a year of CPAP treatment can significantly reduce AHI, improve the level of LSaO2 and serum IGF-1. Serum IGF-1 levels could be used as a monitor of efficacy evaluation.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Fator de Crescimento Insulin-Like I
/
Apneia Obstrutiva do Sono
/
Pressão Positiva Contínua nas Vias Aéreas
Idioma:
Zh
Ano de publicação:
2018
Tipo de documento:
Article