Evaluating prodrug characteristics of a novel anticoagulant fusion protein neorudin, a prodrug targeting release of hirudin variant 2-Lys47 at the thrombosis site, by means of in vitro pharmacokinetics.

Dong, Xiaona; Gu, Ruolan; Zhu, Xiaoxia; Gan, Hui; Liu, Jianglin; Jin, Jide; Meng, Zhiyun; Dou, Guifang

Dong, Xiaona; Gu, Ruolan; Zhu, Xiaoxia; Gan, Hui; Liu, Jianglin; Jin, Jide; Meng, Zhiyun; Dou, Guifang.

Afiliação

Dong X; State Key Laboratory of Drug Metabolism and Pharmacokinetics, Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, China.
Gu R; State Key Laboratory of Drug Metabolism and Pharmacokinetics, Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, China.
Zhu X; State Key Laboratory of Drug Metabolism and Pharmacokinetics, Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, China.
Gan H; State Key Laboratory of Drug Metabolism and Pharmacokinetics, Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, China.
Liu J; Beijing SUYA pharmaceutical lab, INC, China.
Jin J; Laboratory of Experimental Hematology, Beijing Institute of Radiation Medicine, China.
Meng Z; State Key Laboratory of Drug Metabolism and Pharmacokinetics, Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, China. Electronic address: mengzhiyun@vip.163.com.
Dou G; State Key Laboratory of Drug Metabolism and Pharmacokinetics, Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, China. Electronic address: douguifang@vip.163.com.

Eur J Pharm Sci ; 121: 166-177, 2018 08 30.

Article em En | MEDLINE | ID: mdl-29802897

Assuntos

Anticoagulantes/metabolismo; Hirudinas/metabolismo; Pró-Fármacos/metabolismo; Proteínas Recombinantes de Fusão/metabolismo; Animais; Biotransformação; Rim/metabolismo; Fígado/metabolismo; Masculino; Ratos Wistar; Trombose Venosa/metabolismo

Palavras-chave

Anticoagulant fusion protein; Hirudin variant 2-Lys47; In vitro pharmacokinetics; Metabolism; Neorudin; Prodrug; UPLC-MS/MS

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Recombinantes de Fusão / Pró-Fármacos / Hirudinas / Anticoagulantes Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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