Oral diatrizoate acid for meconium-related ileus in extremely preterm infants.
Pediatr Int
; 60(8): 714-718, 2018 Aug.
Article
em En
| MEDLINE
| ID: mdl-29804321
ABSTRACT
BACKGROUND:
Intestinal disorders are common in very low-birthweight infants. The purpose of this study was to evaluate the impact of prophylactic oral Gastrografin® (diatrizoate acid) on meconium-related ileus (MRI) in extremely preterm infants.METHODS:
This was a retrospective case-control study of infants born extremely preterm at <28 weeks of gestation and treated with diatrizoate acid (prophylactic group) or not (control group) in the periods 2007-2014 and 2000-2009, respectively. In the 2007-2014 period, 120 infants received prophylactic diatrizoate acid solution. From the 165 infants in the control group, we selected 120 infants matched for gestational age. Cases of death before 72 h of life or congenital abnormalities were excluded. Intestinal disorders, time until full enteral feeding, duration of hospital stay, mortality rate, and neurodevelopmental outcome were compared.RESULTS:
MRI occurred in six infants in the control group and in none of the infants in the prophylactic group (P = 0.039). Median time until full enteral feeding was 25 versus 22 days (P < 0.01), hospital stay was 142 versus 126 days (P < 0.01), and mortality rate for infants aged 24-27 weeks was 8.2% versus 0% (P = 0.021), respectively.CONCLUSIONS:
Prophylactic oral diatrizoate acid reduced MRI in extremely preterm infants without side-effects and decreased the mortality rate of infants born at 24-27 weeks, and is thus beneficial in extremely preterm infants.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Fármacos Gastrointestinais
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Diatrizoato de Meglumina
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Lactente Extremamente Prematuro
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Íleo Meconial
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Doenças do Prematuro
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article