Iron deficiency in chronic kidney disease patients with diabetes mellitus.
Diabetes Metab Syndr
; 12(6): 933-937, 2018 Nov.
Article
em En
| MEDLINE
| ID: mdl-29804918
ABSTRACT
BACKGROUNDS Iron deficiency has been studied extensively in patients with chronic kidney disease on hemodialysis therapy. However, few studies looked at iron treatment in the non-dialysis chronic kidney disease population. METHODS:
Five hundred and eighty patients were studied (247 were diabetic persons). Patients were divided into 4 groups non-diabetic subjects without CKD, non-diabetic ones with GFRâ¯<â¯60â¯mL/min, diabetic persons without CKD and diabetic ones with GFRâ¯<â¯60â¯mL/min). Iron deficiency was diagnosed when serum ferritin level was <100â¯mg/dl. It was defined as diminished iron availability when ferritin was above 100â¯mg/dl and serum transferrin saturation (TSAT) was <20%.RESULTS:
Anemia was more frequent in the diabetic CKD patients group (52.4%, pâ¯<â¯0.001). Anemia prevalence was also higher in all CKD patients as well as in diabetic patients compared with non-diabetic ones. Iron deficiency was more frequent in diabetic patients. Among CKD diabetic patients the prevalence of iron deficiency was higher than in non-diabetic CKD ones. Diminished iron availability prevalence was higher in non-diabetic patients. Logistic regression analysis showed that only sex and diabetes mellitus were independently associated with iron deficiency.CONCLUSIONS:
Anemia was more common in diabetic CKD patients. Diabetes mellitus was independently associated with iron deficiency. Surprisingly, diminished iron availability was not more frequent in diabetic patients. The physio-pathological mechanisms that could explain these findings remain to be elucidated.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Anemia Ferropriva
/
Complicações do Diabetes
/
Insuficiência Renal Crônica
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article