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Click Chemistry-Based Discovery of [3-Hydroxy-5-(1 H-1,2,3-triazol-4-yl)picolinoyl]glycines as Orally Active Hypoxia-Inducing Factor Prolyl Hydroxylase Inhibitors with Favorable Safety Profiles for the Treatment of Anemia.
Wu, Yue; Jiang, Zhensheng; Li, Zhihong; Gu, Jing; You, Qidong; Zhang, Xiaojin.
Afiliação
  • Wu Y; Sate Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization , China Pharmaceutical University , Nanjing 210009 , China.
  • Jiang Z; Department of Medicinal Chemistry, School of Medicinal Chemistry , China Pharmaceutical University , Nanjing 210009 , China.
  • Li Z; Sate Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization , China Pharmaceutical University , Nanjing 210009 , China.
  • Gu J; Department of Medicinal Chemistry, School of Medicinal Chemistry , China Pharmaceutical University , Nanjing 210009 , China.
  • You Q; Sate Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization , China Pharmaceutical University , Nanjing 210009 , China.
  • Zhang X; Department of Organic Chemistry, School of Science , China Pharmaceutical University , Nanjing 211198 , China.
J Med Chem ; 61(12): 5332-5349, 2018 06 28.
Article em En | MEDLINE | ID: mdl-29856623
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Triazóis / Prolina Dioxigenases do Fator Induzível por Hipóxia / Inibidores de Prolil-Hidrolase / Glicina / Anemia Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Triazóis / Prolina Dioxigenases do Fator Induzível por Hipóxia / Inibidores de Prolil-Hidrolase / Glicina / Anemia Idioma: En Ano de publicação: 2018 Tipo de documento: Article