Heart-specific autoantibodies following murine coxsackievirus B3 myocarditis.
J Exp Med
; 161(5): 1112-21, 1985 May 01.
Article
em En
| MEDLINE
| ID: mdl-2985729
ABSTRACT
The sera from A.SW/SnJ mice infected with Coxsackievirus B3 (CB3) were tested on normal mouse tissue by indirect immunofluorescence. Heart-reactive antibodies were found. Absorption studies with organ extracts showed some of these autoantibodies to be heart-specific. Additional antibodies were crossreactive with skeletal muscle and kidney. These findings suggest a role for autoimmunity in the pathogenesis of murine CB3-induced myocarditis. This study establishes an animal model for the study of the humoral autoimmune response in human viral myocarditis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Autoanticorpos
/
Infecções por Coxsackievirus
/
Miocardite
/
Miocárdio
Idioma:
En
Ano de publicação:
1985
Tipo de documento:
Article