Mitochondrial mechanisms and therapeutics in ischaemia reperfusion injury.
Pediatr Nephrol
; 34(7): 1167-1174, 2019 07.
Article
em En
| MEDLINE
| ID: mdl-29860579
ABSTRACT
Acute kidney injury (AKI) remains a major problem in critically unwell children and young adults. Ischaemia reperfusion (IR) injury is a major contributor to the development of AKI in a significant proportion of these cases and mitochondria are increasingly recognised as being central to this process through generation of a burst of reactive oxygen species early in reperfusion. Mitochondria have additionally been shown to have key roles in downstream processes including activation of the immune response, immunomodulation, and apoptosis and necrosis. The recognition of the central role of mitochondria in IR injury and an increased understanding of the pathophysiology that undermines these processes has resulted in identification of novel therapeutic targets and potential biomarkers. This review summarises a variety of therapeutic approaches that are currently under exploration and may have potential in ameliorating AKI in children in the future.
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Base de dados:
MEDLINE
Assunto principal:
Traumatismo por Reperfusão
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Espécies Reativas de Oxigênio
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Injúria Renal Aguda
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Mitocôndrias
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article