Acyclovir-induced thrombocytopaenia in a patient with SLE.
BMJ Case Rep
; 20182018 Jun 08.
Article
em En
| MEDLINE
| ID: mdl-29884720
ABSTRACT
Acyclovir has been used in the treatment of herpes simplex and varicella zoster viral infections for over 30 years. The side effects of oral treatment at standard doses are rare and include headache, diarrhoea, dizziness and malaise. We report a patient with a new diagnosis of systemic lupus erythematosus (SLE) who developed thrombocytopaenia within days on a therapeutic dose with acyclovir. Prompt discontinuation of acyclovir and treatment with intravenous immunoglobulin resulted in reversal of the above potentially serious complication. Therefore a high index of suspicion should be exercised in patients with SLE who require treatment with acyclovir for herpes viral infections. In these patients regular platelet count measurement should be considered while on treatment with the above antiviral agent.
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Base de dados:
MEDLINE
Assunto principal:
Trombocitopenia
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Aciclovir
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Imunoglobulinas Intravenosas
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Herpes Zoster
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Lúpus Eritematoso Sistêmico
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article