The Relationship of Dietary Cholesterol with Serum Low-Density Lipoprotein Cholesterol and Confounding by Reverse Causality: The INTERLIPID Study.
J Atheroscler Thromb
; 26(2): 170-182, 2019 Feb 01.
Article
em En
| MEDLINE
| ID: mdl-29887537
ABSTRACT
AIM:
The positive relationship between dietary cholesterol and serum cholesterol has been questioned by a set of recent cohort studies. This study aimed to investigate how employment status and education years relate to the association between dietary cholesterol and serum low-density lipoprotein cholesterol (LDL-C) in a Japanese population.METHODS:
A population-based, random sample, cross-sectional study (INTERLIPID) was performed. Among 1,145 Japanese individuals aged 40-59 years, 106 were excluded because of special diets, use of lipid-lowering drugs, hormone replacement, and missing data, leaving 1,039 individuals (533 men and 506 women). Dietary cholesterol was assessed from four 24-h dietary recalls, and LDL-C was measured enzymatically with an auto-analyzer. A standard questionnaire inquired about employment status and education years.RESULTS:
In men, a 1 standard deviation (SD) higher dietary cholesterol was associated with 3.16 mg/dL lower serum LDL-C (P=0.009; unadjusted model). After adjustment for covariates, higher serum LDL-C was estimated per 1 SD higher intake of dietary cholesterol in nonemployed men [self-employed, homemakers, farmers, fishermen, and retired employees; ß=ï¼9.08, 95% confidence interval (CI)=ï¼0.90-ï¼17.27] and less educated men (ß=ï¼4.46, 95% CI=ï¼0.97-ï¼9.90), whereas an inverse association was observed in employed men (ß=ï¼3.02, 95% CI=ï¼5.49-ï¼0.54) and more educated men (ß=ï¼3.66, 95% CI=ï¼6.25-ï¼1.07).CONCLUSIONS:
In men who were nonemployed and less educated, a higher intake of dietary cholesterol was associated with elevated concentrations of serum LDL-C, whereas an inverse association was observed in men who were employed and more educated.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Colesterol na Dieta
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Biomarcadores
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Doença das Coronárias
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LDL-Colesterol
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article