Leptin Promotes Allergic Airway Inflammation through Targeting the Unfolded Protein Response Pathway.
Sci Rep
; 8(1): 8905, 2018 06 11.
Article
em En
| MEDLINE
| ID: mdl-29891850
ABSTRACT
Allergic asthma and obesity are major public health problems in the world. Recent Meta-analysis studies implicated a positive relationship between serum leptin, which is elevated in obese individuals, and the risk of asthma. However, it is not well understood how obesity-associated elevation of leptin increases the risk of asthma. In the current study, we have found that leptin induces the unfolded protein response factor XBP1s in an mTOR- and MAPK-dependent manner in pro-allergic TH2 cells; in vivo, mice fed with high fat diet had increased serum leptin as observed in human obese population and exacerbated asthmatic symptoms, associated with increased XBP1s expression in splenic CD4+ T cells. XBP1s is required for leptin-mediated pro-allergic TH2 cell survival and cytokine production. Our results reveal a previously unappreciated insight that obesity-associated hyperleptinemia contributes to enhanced pro-allergic lymphocyte responses through induction of XBP1s, leading to exacerbation of allergic asthma.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Asma
/
Células Th2
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Leptina
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Resposta a Proteínas não Dobradas
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Proteína 1 de Ligação a X-Box
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Inflamação
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article