Intrachromosomal colocalization strengthens co-expression, co-modification and evolutionary conservation of neighboring genes.
BMC Genomics
; 19(1): 455, 2018 Jun 13.
Article
em En
| MEDLINE
| ID: mdl-29898652
ABSTRACT
BACKGROUND:
Gene order and location in chromosomes of species are non-random. Neighboring gene pairs tend to display some similarities, such as co-expression and co-modification. However, the contribution of linear proximity, spatial proximity, and evolutionary proximity to these similarities remain unclear, together with whether the presence of several types of proximity can strengthens the similarities.RESULTS:
In this study, we investigated the properties of three kinds of colocalized gene pairs intrachromosomal colocalized gene pairs, always-neighboring gene pairs, and evolutionary neighboring gene pairs. Our analysis showed that (1) Different types of colocalized genes differentially contribute to co-expression, co-modifications and conservation across species; (2) Intrachromosomal colocalization can strengthen co-expression and co-modification of neighboring gene pairs and their conservation across species; (3) The combination of the three kinds of colocalization can lead to the strongest co-modification and is most strongly conserved across species. (4) Colocalized gene pairs are indicative of phylogenetic relationships and whole genome duplications (WGDs).CONCLUSIONS:
These results provide valuable clues for future efforts to understand the characteristics of colocalized gene pairs and how the neighborhood affects their interactions.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Expressão Gênica
/
Evolução Molecular
/
Cromossomos de Plantas
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article