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Olfactory impairment in first-episode schizophrenia: a case-control study, and sex dimorphism in the relationship between olfactory impairment and psychotic symptoms.
Chen, Xiacan; Xu, Jiajun; Li, Bin; Guo, Wanjun; Zhang, Jun; Hu, Junmei.
Afiliação
  • Chen X; West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Sichuan, China.
  • Xu J; Mental Health Center, West China Hospital, Sichuan University, Sichuan, China. xujiajun120@126.com.
  • Li B; Mental Health Center, West China Hospital, Sichuan University, Sichuan, China.
  • Guo W; Mental Health Center, West China Hospital, Sichuan University, Sichuan, China.
  • Zhang J; Mental Health Center, West China Hospital, Sichuan University, Sichuan, China.
  • Hu J; West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Sichuan, China. junmeihu@hotmail.com.
BMC Psychiatry ; 18(1): 199, 2018 06 18.
Article em En | MEDLINE | ID: mdl-29914416
BACKGROUND: A body of studies has focused on the olfactory impairment among people with schizophrenia. The effect of sex on this relationship has attracted the attention of researchers. These issues have not been studied much in Chinese schizophrenia patients. METHODS: We conducted a case-control study of 110 first-episode antipsychotic medicine naïve schizophrenia patients aged 18-35 years and 110 controls, matched by age and sex. Odour threshold, discrimination and identification were assessed by the "Sniffin' Sticks" test. Psychotic symptoms were assessed by the Positive and Negative Syndrome Scale (PANSS). RESULTS: The odour threshold, discrimination and identification scores of patients with schizophrenia were significantly lower than those of the healthy control group. The difference in identification score had statistical significance between male and female patients with schizophrenia (t = - 2.45, P < 0.05). Controlling for confounding factor, in male schizophrenia participants, the negative subscale score was significantly and inversely correlated with the discrimination (γ = - 0.37, p < 0.008), identification (γ = - 0.45, p < 0.008) and TDI (γ = - 0.50, p < 0.008) scores; the general psychopathology subscale score was inversely and significantly correlated with the identification (γ = - 0.47, p < 0.008) and TDI (γ = - 0.41, p < 0.008) scores. For female schizophrenia patients, positive and general psychopathology subscale scores had a significant inverse correlation with the identification score (positive: γ = - 0.47, p < 0.008; general psychopathology: γ = - 0.42, p < 0.008). CONCLUSIONS: Controlling for confounder, negative symptoms were related to impaired odour discrimination and identification in male schizophrenia patients, while positive symptoms were correlated with impaired odour identification in female schizophrenia patients. This sex dimorphism could provide useful information for future studies aiming to finding biomarkers of schizophrenia.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtornos Psicóticos / Esquizofrenia / Caracteres Sexuais / Transtornos do Olfato Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtornos Psicóticos / Esquizofrenia / Caracteres Sexuais / Transtornos do Olfato Idioma: En Ano de publicação: 2018 Tipo de documento: Article