Exploration of a F(ab')<sub>2</sub> Fragment as the Targeting Agent of &#945;-Radiation Therapy: A Comparison of the Therapeutic Benefit of Intraperitoneal and Intravenous Administered Radioimmunotherapy.

Milenic, Diane E; Kim, Young-Seung; Baidoo, Kwamena E; Wong, Karen J; Barkley, Rachel; Delgado, Jose; Brechbiel, Martin W

Exploration of a F(ab')₂ Fragment as the Targeting Agent of α-Radiation Therapy: A Comparison of the Therapeutic Benefit of Intraperitoneal and Intravenous Administered Radioimmunotherapy.

Milenic, Diane E; Kim, Young-Seung; Baidoo, Kwamena E; Wong, Karen J; Barkley, Rachel; Delgado, Jose; Brechbiel, Martin W.

Afiliação

Milenic DE; 1 Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health , Bethesda, Maryland.
Kim YS; 1 Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health , Bethesda, Maryland.
Baidoo KE; 1 Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health , Bethesda, Maryland.
Wong KJ; 2 Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health , Bethesda, Maryland.
Barkley R; 1 Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health , Bethesda, Maryland.
Delgado J; 1 Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health , Bethesda, Maryland.
Brechbiel MW; 1 Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health , Bethesda, Maryland.

Cancer Biother Radiopharm ; 33(5): 182-193, 2018 Jun.

Article em En | MEDLINE | ID: mdl-29916748

Assuntos

Partículas alfa; Anticorpos Monoclonais/administração & dosagem; Neoplasias do Colo/terapia; Receptores ErbB/antagonistas & inibidores; Radioisótopos de Chumbo/uso terapêutico; Radioimunoterapia; Administração Intravenosa; Animais; Apoptose; Proliferação de Células; Neoplasias do Colo/imunologia; Neoplasias do Colo/patologia; Receptores ErbB/imunologia; Feminino; Humanos; Fragmentos Fab das Imunoglobulinas/imunologia; Injeções Intraperitoneais; Camundongos; Camundongos Nus; Panitumumabe; Células Tumorais Cultivadas; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

212Pb; F(ab')2; HER1; intraperitoneal; radioimmunotherapy; α-radiation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Radioisótopos de Chumbo / Radioimunoterapia / Neoplasias do Colo / Partículas alfa / Receptores ErbB / Anticorpos Monoclonais Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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