Plasma CRABP2 as a Novel Biomarker in Patients with Non-Small Cell Lung Cancer.
J Korean Med Sci
; 33(26): e178, 2018 Jun 25.
Article
em En
| MEDLINE
| ID: mdl-29930489
ABSTRACT
BACKGROUND:
Lung cancer is the most common cause of cancer-related mortality worldwide. We previously reported the identification of a new genetic marker, cellular retinoic acid binding protein 2 (CRABP2), in lung cancer tissues. The aim of this study was to assess plasma levels of CRABP2 from patients with non-small cell lung cancer (NSCLC).METHODS:
Blood samples that were collected from 122 patients with NSCLC between September 2009 and September 2013 were selected for the analysis, along with samples from age- (± 5 years), sex-, and cigarette smoking history (± 10 pack-years [PY])-matched controls from the Korea Biobank Network. The control specimens were from patients who were without malignancies or pulmonary diseases. We measured plasma levels of CRABP2 using commercially available enzyme-linked immunosorbent assay kits.RESULTS:
The mean age of the NSCLC patients was 71.8 ± 8.9 years, and the median cigarette smoking history was 32 PY (range, 0-150 PY). Plasma CRABP2 levels were significantly higher in patients with NSCLC than in the matched controls (37.63 ± 28.71 ng/mL vs. 24.09 ± 21.09 ng/mL, P < 0.001). Higher plasma CRABP2 levels were also correlated with lower survival rates in NSCLC patients (P = 0.014).CONCLUSION:
Plasma CRABP2 levels might be a novel diagnostic and prognostic marker in NSCLC.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Receptores do Ácido Retinoico
/
Carcinoma Pulmonar de Células não Pequenas
/
Neoplasias Pulmonares
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article