Genomics of Peritoneal Malignancies.
Surg Oncol Clin N Am
; 27(3): 463-475, 2018 07.
Article
em En
| MEDLINE
| ID: mdl-29935683
ABSTRACT
The peritoneum protects the intraabdominal organs. This function is exploited by aggressive cancers originating from organs within the abdomen, resulting in peritoneal metastasis. We discuss genomic variants that may lead to peritoneal metastasis from multiple cancers. Peritoneal malignancies are attributed to epithelial-mesenchymal transition. These metastatic lesions harbor similar genetic mutations to the primary tumor yet may manifest clone-specific aberrations that promote propagation. Peritoneal metastasis are increasingly being treated with surgical resection as an adjunct to radiation, chemotherapy, and other biologic therapies. We describe genetic and genomic variances that are predictive markers for metastasis and burgeoning indicators for peritoneal malignancies.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Peritoneais
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Biomarcadores Tumorais
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Genômica
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article