Colloidal stability of superparamagnetic iron oxide nanoparticles in the central nervous system: a review.
Nanomedicine (Lond)
; 13(11): 1385-1400, 2018 06.
Article
em En
| MEDLINE
| ID: mdl-29949472
ABSTRACT
Superparamagnetic iron oxide nanoparticles (SPIONs) consist of nanosized metallic-based particles with unique magnetic properties. Their potential in both diagnostic and therapeutic applications in the CNS is at the source of an expanding body of the literature in recent years. Colloidal stability of nanoparticles represents their ability to resist aggregation and is a central aspect for the use of SPION in biological environment such as the CNS. This review gives a comprehensive update of the recent developments and knowledge on the determinants of colloidal stability of SPIONs in the CNS. Factors leading to aggregate formation and the repercussions of colloidal instability of SPION are reviewed in detail pertaining to their use in the CNS.
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1
Base de dados:
MEDLINE
Assunto principal:
Compostos Férricos
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Sistema Nervoso Central
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Nanopartículas de Magnetita
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article