Forkhead box protein 3 (FoxP3) mRNA as a diagnostic marker in ovarian tumors: a pilot study.
Eur J Gynaecol Oncol
; 38(2): 251-256, 2017.
Article
em En
| MEDLINE
| ID: mdl-29953790
ABSTRACT
PURPOSE:
To assess the diagnostic performance of forkhead box protein 3 (FoxP3) mRNA in ovarian tumors. MATERIALS ANDMETHODS:
Using quantitative real time reverse transcription PCR (q-RT-PCR), FoxP3 mRNA level was measured in fresh frozen ovarian tumors and its diagnostic performance was compared to those of preoperative serum CA 125 and risk of malignancy index (RMI).RESULTS:
FoxP3 mRNA was differentially expressed in the malignant (n = 25) and benign (n = 25) groups, yet without statistically significant differences; positivity rate 15/25 vs. 10/25; p = 0.157, median 0.429 vs. 0.046; p = 0.684, and mean ± SD 73.75 ± 234.68 vs. 247.09 ± 792.17; p = 0.30 1. Although it showed much less diagnostic performance (AUC 0.534), FoxP3 mRNA enhanced the diagnostic sensitivity and specificity of both CA125 and RMI (96% and 100%, for both).CONCLUSION:
FoxP3 mRNA may not be good diagnostic marker in ovarian tumors; however it may prove valuable in defining underlying tumor molecular signature.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Ovarianas
/
RNA Mensageiro
/
Fatores de Transcrição Forkhead
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article