Inhibitory effect of 11-carbonyl-beta-boswellic acid on non-small cell lung cancer H446 cells.
Biochem Biophys Res Commun
; 503(4): 2202-2205, 2018 09 18.
Article
em En
| MEDLINE
| ID: mdl-29953860
ABSTRACT
BACKGROUND:
The anti-lung tumor potential of 11-carbonyl-ß-boswellic acid was investigated. MATERIALS &METHODS:
The inhibitory effects of 11-carbonyl-ß-boswellic acid on non-small cell lung cancer (NSCLC) was assessed by proliferation, apoptosis, cell cycle and molecular mechanisms in NSCLC H446â¯cells in vitro. The results showed that the growth of H446â¯cells was significantly inhibited by 11-carbonyl-ß-boswellic acid in a dose- and time-dependent manner. Meanwhile, 11-carbonyl-ß-boswellic acid induced cell apoptosis and cell cycle G2-M phase arrest in H446â¯cells.RESULTS:
Mechanistically, 11-carbonyl-ß-boswellic acid could activate JNK signaling pathway, down-regulate the expression of surviving protein, and activate the cleavage of PARP, leading to marked inhibitory effect on H446â¯cells.CONCLUSIONS:
These findings suggest that 11-carbonyl-ß-boswellic acid may be a potential usefulness for preventing and treatment of NSCLC.Palavras-chave
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MEDLINE
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Triterpenos
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Carcinoma Pulmonar de Células não Pequenas
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article