Oridonin enhances the cytotoxicity of 5-FU in renal carcinoma cells by inducting necroptotic death.

Zheng, Wei; Zhou, Chun-Yan; Zhu, Xin-Qing; Wang, Xue-Jian; Li, Zi-Yao; Chen, Xiao-Chi; Chen, Feng; Che, Xiang-Yu; Xie, Xin

Zheng, Wei; Zhou, Chun-Yan; Zhu, Xin-Qing; Wang, Xue-Jian; Li, Zi-Yao; Chen, Xiao-Chi; Chen, Feng; Che, Xiang-Yu; Xie, Xin.

Afiliação

Zheng W; Department of Urology, First Affiliated Hospital of Dalian Medical University, Dalian, 116011, China.
Zhou CY; Department of Pharmacy, First Affiliated Hospital of Dalian Medical University, Dalian, 116011, China.
Zhu XQ; Department of Urology, First Affiliated Hospital of Dalian Medical University, Dalian, 116011, China.
Wang XJ; Department of Urology, First Affiliated Hospital of Dalian Medical University, Dalian, 116011, China.
Li ZY; Department of Urology, First Affiliated Hospital of Dalian Medical University, Dalian, 116011, China.
Chen XC; Department of Urology, First Affiliated Hospital of Dalian Medical University, Dalian, 116011, China.
Chen F; Department of Urology, First Affiliated Hospital of Dalian Medical University, Dalian, 116011, China.
Che XY; Department of Urology, First Affiliated Hospital of Dalian Medical University, Dalian, 116011, China. Electronic address: dalianchexiangyu@163.com.
Xie X; Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, Dalian, 116011, China. Electronic address: xiexin_phd@163.com.

Biomed Pharmacother ; 106: 175-182, 2018 Oct.

Article em En | MEDLINE | ID: mdl-29958141

Assuntos

Protocolos de Quimioterapia Combinada Antineoplásica/farmacologia; Apoptose/efeitos dos fármacos; Carcinoma de Células Renais/tratamento farmacológico; Diterpenos do Tipo Caurano/farmacologia; Fluoruracila/farmacologia; Neoplasias Renais/tratamento farmacológico; Animais; Carcinoma de Células Renais/metabolismo; Carcinoma de Células Renais/patologia; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Relação Dose-Resposta a Droga; Glutationa/metabolismo; Proteína HMGB1/metabolismo; Humanos; Neoplasias Renais/metabolismo; Neoplasias Renais/patologia; L-Lactato Desidrogenase/metabolismo; Camundongos Nus; Proteínas Quinases Ativadas por Mitógeno/metabolismo; Necrose; Estresse Oxidativo/efeitos dos fármacos; Poli(ADP-Ribose) Polimerase-1/metabolismo; Espécies Reativas de Oxigênio/metabolismo; Proteína Serina-Treonina Quinases de Interação com Receptores/metabolismo; Transdução de Sinais/efeitos dos fármacos; Carga Tumoral/efeitos dos fármacos; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

5-FU; Necroptosis; Oridonin; Renal cell carcinoma

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinoma de Células Renais / Protocolos de Quimioterapia Combinada Antineoplásica / Apoptose / Diterpenos do Tipo Caurano / Fluoruracila / Neoplasias Renais Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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