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Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium.
van Erp, Theo G M; Walton, Esther; Hibar, Derrek P; Schmaal, Lianne; Jiang, Wenhao; Glahn, David C; Pearlson, Godfrey D; Yao, Nailin; Fukunaga, Masaki; Hashimoto, Ryota; Okada, Naohiro; Yamamori, Hidenaga; Bustillo, Juan R; Clark, Vincent P; Agartz, Ingrid; Mueller, Bryon A; Cahn, Wiepke; de Zwarte, Sonja M C; Hulshoff Pol, Hilleke E; Kahn, René S; Ophoff, Roel A; van Haren, Neeltje E M; Andreassen, Ole A; Dale, Anders M; Doan, Nhat Trung; Gurholt, Tiril P; Hartberg, Cecilie B; Haukvik, Unn K; Jørgensen, Kjetil N; Lagerberg, Trine V; Melle, Ingrid; Westlye, Lars T; Gruber, Oliver; Kraemer, Bernd; Richter, Anja; Zilles, David; Calhoun, Vince D; Crespo-Facorro, Benedicto; Roiz-Santiañez, Roberto; Tordesillas-Gutiérrez, Diana; Loughland, Carmel; Carr, Vaughan J; Catts, Stanley; Cropley, Vanessa L; Fullerton, Janice M; Green, Melissa J; Henskens, Frans A; Jablensky, Assen; Lenroot, Rhoshel K; Mowry, Bryan J.
Afiliação
  • van Erp TGM; Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine, California. Electronic address: tvanerp@uci.edu.
  • Walton E; Imaging Genetics and Neuroinformatics Lab, Georgia State University, Atlanta, Georgia.
  • Hibar DP; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, California; Janssen Research & Development, San Diego, California.
  • Schmaal L; Orygen, The National Centre of Excellence in Youth Mental Health, Melbourne, Victoria, Australia; Centre for Youth Mental Health, University of Melbourne, Melbourne, Victoria, Australia; Department of Psychiatry and Neuroscience, VU University Medical Center, Amsterdam, The Netherlands.
  • Jiang W; Department of Psychology, Georgia State University, Atlanta, Georgia.
  • Glahn DC; Department of Psychiatry, Yale University, New Haven, Connecticut; Olin Neuropsychiatric Research Center, Institute of Living, Hartford Hospital, Hartford, Connecticut.
  • Pearlson GD; Department of Psychiatry, Yale University, New Haven, Connecticut; Olin Neuropsychiatric Research Center, Institute of Living, Hartford Hospital, Hartford, Connecticut.
  • Yao N; Department of Psychiatry, Yale University, New Haven, Connecticut; Olin Neuropsychiatric Research Center, Institute of Living, Hartford Hospital, Hartford, Connecticut.
  • Fukunaga M; Division of Cerebral Integration, National Institute for Physiological Sciences, Okazaki, Aichi, Japan.
  • Hashimoto R; Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Suita, Osaka, Japan; Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
  • Okada N; Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan.
  • Yamamori H; Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
  • Bustillo JR; Department of Psychiatry, University of New Mexico, Albuquerque, New Mexico.
  • Clark VP; Department of Psychiatry, University of New Mexico, Albuquerque, New Mexico; Mind Research Network, Albuquerque, New Mexico.
  • Agartz I; Institute of Clinical Medicine, Norwegian Centre for Mental Disorders Research (NORMENT), K.G. Jebsen Centre for Psychosis Research, University of Oslo, Oslo, Norway; Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway; Department of Clinical Neuroscience, Karolinska Institutet,
  • Mueller BA; Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota.
  • Cahn W; Department of Psychiatry and Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
  • de Zwarte SMC; Department of Psychiatry and Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
  • Hulshoff Pol HE; Department of Psychiatry and Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
  • Kahn RS; Department of Psychiatry and Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
  • Ophoff RA; Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, California; Department of Psychiatry and Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
  • van Haren NEM; Department of Child and Adolescent Psychiatry/Psychology, Erasmus Medical Centre, Rotterdam, The Netherlands; Department of Psychiatry and Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
  • Andreassen OA; Institute of Clinical Medicine, Norwegian Centre for Mental Disorders Research (NORMENT), K.G. Jebsen Centre for Psychosis Research, University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, NORMENT, K.G. Jebsen Centre for Psychosis Research, Oslo University Hospital, Oslo, Norway.
  • Dale AM; Center for Translational Imaging and Precision Medicine, San Diego, California; Department of Neurosciences, University of California, San Diego, La Jolla, California; Department of Radiology, University of California, San Diego, La Jolla, California; Department of Psychiatry, University of Californ
  • Doan NT; Institute of Clinical Medicine, Norwegian Centre for Mental Disorders Research (NORMENT), K.G. Jebsen Centre for Psychosis Research, University of Oslo, Oslo, Norway.
  • Gurholt TP; Institute of Clinical Medicine, Norwegian Centre for Mental Disorders Research (NORMENT), K.G. Jebsen Centre for Psychosis Research, University of Oslo, Oslo, Norway; Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway.
  • Hartberg CB; Institute of Clinical Medicine, Norwegian Centre for Mental Disorders Research (NORMENT), K.G. Jebsen Centre for Psychosis Research, University of Oslo, Oslo, Norway.
  • Haukvik UK; Institute of Clinical Medicine, Norwegian Centre for Mental Disorders Research (NORMENT), K.G. Jebsen Centre for Psychosis Research, University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, NORMENT, K.G. Jebsen Centre for Psychosis Research, Oslo University Hospital, Oslo, Norway.
  • Jørgensen KN; Institute of Clinical Medicine, Norwegian Centre for Mental Disorders Research (NORMENT), K.G. Jebsen Centre for Psychosis Research, University of Oslo, Oslo, Norway; Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway.
  • Lagerberg TV; Division of Mental Health and Addiction, NORMENT, K.G. Jebsen Centre for Psychosis Research, Oslo University Hospital, Oslo, Norway.
  • Melle I; Institute of Clinical Medicine, Norwegian Centre for Mental Disorders Research (NORMENT), K.G. Jebsen Centre for Psychosis Research, University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, NORMENT, K.G. Jebsen Centre for Psychosis Research, Oslo University Hospital, Oslo, Norway.
  • Westlye LT; Department of Psychology, University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, NORMENT, K.G. Jebsen Centre for Psychosis Research, Oslo University Hospital, Oslo, Norway.
  • Gruber O; Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University Hospital, Heidelberg, Germany; Center for Translational Research in Systems Neuroscience and Psychiatry, Department of Psychiatry, Georg August University, Göttingen, Germany.
  • Kraemer B; Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University Hospital, Heidelberg, Germany; Center for Translational Research in Systems Neuroscience and Psychiatry, Department of Psychiatry, Georg August University, Göttingen, Germany.
  • Richter A; Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University Hospital, Heidelberg, Germany; Center for Translational Research in Systems Neuroscience and Psychiatry, Department of Psychiatry, Georg August University, Göttingen, Germany.
  • Zilles D; Center for Translational Research in Systems Neuroscience and Psychiatry, Department of Psychiatry, Georg August University, Göttingen, Germany; Department of Psychiatry, University Medical Center Göttingen, Göttingen, Germany.
  • Calhoun VD; Department of Psychiatry, University of New Mexico, Albuquerque, New Mexico; Mind Research Network, Albuquerque, New Mexico.
  • Crespo-Facorro B; Department of Psychiatry, University Hospital Marqués de Valdecilla, School of Medicine, Marqués de Valdecilla Research Institute (IDIVAL), University of Cantabria, Santander, Spain; Centro Investigación Biomédica en Red de Salud Mental, Santander, Spain.
  • Roiz-Santiañez R; Department of Psychiatry, University Hospital Marqués de Valdecilla, School of Medicine, Marqués de Valdecilla Research Institute (IDIVAL), University of Cantabria, Santander, Spain; Centro Investigación Biomédica en Red de Salud Mental, Santander, Spain.
  • Tordesillas-Gutiérrez D; Department of Psychiatry, University Hospital Marqués de Valdecilla, School of Medicine, Marqués de Valdecilla Research Institute (IDIVAL), University of Cantabria, Santander, Spain; Neuroimaging Unit, Technological Facilities, Valdecilla Biomedical Research Institute, Marqués de Valdecilla Research
  • Loughland C; Priority Research Centre for Brain & Mental Health, University of Newcastle, Newcastle, New South Wales, Australia; Hunter Medical Research Institute, Newcastle, New South Wales, Australia; Hunter New England Local Health District, Newcastle, New South Wales, Australia.
  • Carr VJ; Department of Psychiatry, Monash University, Melbourne, Victoria, Australia; School of Psychiatry, University of New South Wales, New South Wales, Australia.
  • Catts S; Discipline of Psychiatry, School of Medicine, University of Queensland, Brisbane, Queensland, Australia.
  • Cropley VL; Neuropsychiatry Centre, University of Melbourne, Melbourne, Victoria, Australia.
  • Fullerton JM; School of Medical Sciences, University of New South Wales, New South Wales, Australia; Neuroscience Research Australia, Sydney, New South Wales, Australia.
  • Green MJ; School of Psychiatry, University of New South Wales, New South Wales, Australia; Neuroscience Research Australia, Sydney, New South Wales, Australia.
  • Henskens FA; Priority Research Centre for Health Behaviour, University of Newcastle, Newcastle, New South Wales, Australia; School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, Australia; Hunter Medical Research Institute, Newcastle, New South Wales, Australia.
  • Jablensky A; School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, Western Australia, Australia.
  • Lenroot RK; School of Psychiatry, University of New South Wales, New South Wales, Australia; Neuroscience Research Australia, Sydney, New South Wales, Australia.
  • Mowry BJ; Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia; Queensland Centre for Mental Health Research, University of Queensland, Brisbane, Queensland, Australia.
Biol Psychiatry ; 84(9): 644-654, 2018 11 01.
Article em En | MEDLINE | ID: mdl-29960671
BACKGROUND: The profile of cortical neuroanatomical abnormalities in schizophrenia is not fully understood, despite hundreds of published structural brain imaging studies. This study presents the first meta-analysis of cortical thickness and surface area abnormalities in schizophrenia conducted by the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Schizophrenia Working Group. METHODS: The study included data from 4474 individuals with schizophrenia (mean age, 32.3 years; range, 11-78 years; 66% male) and 5098 healthy volunteers (mean age, 32.8 years; range, 10-87 years; 53% male) assessed with standardized methods at 39 centers worldwide. RESULTS: Compared with healthy volunteers, individuals with schizophrenia have widespread thinner cortex (left/right hemisphere: Cohen's d = -0.530/-0.516) and smaller surface area (left/right hemisphere: Cohen's d = -0.251/-0.254), with the largest effect sizes for both in frontal and temporal lobe regions. Regional group differences in cortical thickness remained significant when statistically controlling for global cortical thickness, suggesting regional specificity. In contrast, effects for cortical surface area appear global. Case-control, negative, cortical thickness effect sizes were two to three times larger in individuals receiving antipsychotic medication relative to unmedicated individuals. Negative correlations between age and bilateral temporal pole thickness were stronger in individuals with schizophrenia than in healthy volunteers. Regional cortical thickness showed significant negative correlations with normalized medication dose, symptom severity, and duration of illness and positive correlations with age at onset. CONCLUSIONS: The findings indicate that the ENIGMA meta-analysis approach can achieve robust findings in clinical neuroscience studies; also, medication effects should be taken into account in future genetic association studies of cortical thickness in schizophrenia.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Esquizofrenia / Encéfalo Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Esquizofrenia / Encéfalo Idioma: En Ano de publicação: 2018 Tipo de documento: Article