Design, synthesis and evaluation of novel bivalent ß-carboline derivatives as multifunctional agents for the treatment of Alzheimer's disease.

Zhao, Yifan; Ye, Feng; Xu, Jian; Liao, Qinghong; Chen, Lei; Zhang, Weijia; Sun, Haopeng; Liu, Wenyuan; Feng, Feng; Qu, Wei

Zhao, Yifan; Ye, Feng; Xu, Jian; Liao, Qinghong; Chen, Lei; Zhang, Weijia; Sun, Haopeng; Liu, Wenyuan; Feng, Feng; Qu, Wei.

Afiliação

Zhao Y; School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
Ye F; School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
Xu J; School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
Liao Q; School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
Chen L; Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, China.
Zhang W; School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
Sun H; Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
Liu W; Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, China.
Feng F; School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China; Key Laboratory of Biomedical Functional Materials, China Pharmaceutical University, Nanjing 210009, China; Jiangsu Food and Pharmaceutical Science College, Huaian 223003, China. Electronic address: fengfe
Qu W; School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China; Key Laboratory of Biomedical Functional Materials, China Pharmaceutical University, Nanjing 210009, China. Electronic address: popoqzh@126.com.

Bioorg Med Chem ; 26(13): 3812-3824, 2018 07 30.

Article em En | MEDLINE | ID: mdl-29960728

Assuntos

Carbolinas/química; Inibidores da Colinesterase/síntese química; Desenho de Fármacos; Fármacos Neuroprotetores/síntese química; Acetilcolinesterase/química; Acetilcolinesterase/metabolismo; Doença de Alzheimer/metabolismo; Doença de Alzheimer/patologia; Peptídeos beta-Amiloides/antagonistas & inibidores; Peptídeos beta-Amiloides/metabolismo; Sítios de Ligação; Butirilcolinesterase/química; Butirilcolinesterase/metabolismo; Carbolinas/metabolismo; Carbolinas/farmacologia; Linhagem Celular Tumoral; Sobrevivência Celular/efeitos dos fármacos; Inibidores da Colinesterase/metabolismo; Inibidores da Colinesterase/farmacologia; Humanos; Peróxido de Hidrogênio/toxicidade; Concentração Inibidora 50; Simulação de Acoplamento Molecular; Fármacos Neuroprotetores/farmacologia; Ácido Okadáico/toxicidade; Fragmentos de Peptídeos/antagonistas & inibidores; Fragmentos de Peptídeos/metabolismo; Estrutura Terciária de Proteína; Relação Estrutura-Atividade

Palavras-chave

Alzheimer's disease; Aß(1-42) aggregation inhibitory; Bivalent ß-carbolines; Neuroprotective activity

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carbolinas / Desenho de Fármacos / Inibidores da Colinesterase / Fármacos Neuroprotetores Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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