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Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates.
Dudley, Dawn M; Van Rompay, Koen K; Coffey, Lark L; Ardeshir, Amir; Keesler, Rebekah I; Bliss-Moreau, Eliza; Grigsby, Peta L; Steinbach, Rosemary J; Hirsch, Alec J; MacAllister, Rhonda P; Pecoraro, Heidi L; Colgin, Lois M; Hodge, Travis; Streblow, Daniel N; Tardif, Suzette; Patterson, Jean L; Tamhankar, Manasi; Seferovic, Maxim; Aagaard, Kjersti M; Martín, Claudia Sánchez-San; Chiu, Charles Y; Panganiban, Antonito T; Veazey, Ronald S; Wang, Xiaolei; Maness, Nicholas J; Gilbert, Margaret H; Bohm, Rudolf P; Adams Waldorf, Kristina M; Gale, Michael; Rajagopal, Lakshmi; Hotchkiss, Charlotte E; Mohr, Emma L; Capuano, Saverio V; Simmons, Heather A; Mejia, Andres; Friedrich, Thomas C; Golos, Thaddeus G; O'Connor, David H.
Afiliação
  • Dudley DM; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI, USA.
  • Van Rompay KK; California National Primate Research Center, University of California-Davis, Davis, CA, USA. kkvanrompay@ucdavis.edu.
  • Coffey LL; Department of Pathology, Microbiology, and Immunology, University of California-Davis, Davis, CA, USA. kkvanrompay@ucdavis.edu.
  • Ardeshir A; Department of Pathology, Microbiology, and Immunology, University of California-Davis, Davis, CA, USA.
  • Keesler RI; California National Primate Research Center, University of California-Davis, Davis, CA, USA.
  • Bliss-Moreau E; California National Primate Research Center, University of California-Davis, Davis, CA, USA.
  • Grigsby PL; California National Primate Research Center, University of California-Davis, Davis, CA, USA.
  • Steinbach RJ; Department of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Portland, OR, USA.
  • Hirsch AJ; Department of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Portland, OR, USA.
  • MacAllister RP; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, OR, USA.
  • Pecoraro HL; Division of Pathobiology and Immunology, Oregon National Primate Research Center, Portland, OR, USA.
  • Colgin LM; Division of Comparative Medicine, Oregon National Primate Research Center, Portland, OR, USA.
  • Hodge T; Pathology Services Unit, Division of Comparative Medicine, Oregon National Primate Research Center, Portland, OR, USA.
  • Streblow DN; Pathology Services Unit, Division of Comparative Medicine, Oregon National Primate Research Center, Portland, OR, USA.
  • Tardif S; Division of Comparative Medicine, Oregon National Primate Research Center, Portland, OR, USA.
  • Patterson JL; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, OR, USA. streblow@ohsu.edu.
  • Tamhankar M; Division of Pathobiology and Immunology, Oregon National Primate Research Center, Portland, OR, USA. streblow@ohsu.edu.
  • Seferovic M; Southwest National Primate Research Center, Southwest Foundation for Biomedical Research, San Antonio, TX, USA. stardif@txbiomed.org.
  • Aagaard KM; Department of Virology and Immunology, Texas Biomedical Research Institute, San Antonio, TX, USA.
  • Martín CS; Department of Virology and Immunology, Texas Biomedical Research Institute, San Antonio, TX, USA.
  • Chiu CY; Departments of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX, USA.
  • Panganiban AT; Departments of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX, USA.
  • Veazey RS; Department of Molecular and Human Genetics at Baylor College of Medicine, Houston, TX, USA.
  • Wang X; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.
  • Maness NJ; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.
  • Gilbert MH; Department of Medicine/Infectious Diseases, University of California, San Francisco, San Francisco, CA, USA.
  • Bohm RP; Division of Microbiology, Tulane National Primate Research Center, New Orleans, LA, USA. apanagani@tulane.edu.
  • Adams Waldorf KM; Department of Microbiology and Immunology, Tulane University Health Sciences Center, New Orleans, LA, USA. apanagani@tulane.edu.
  • Gale M; Division of Comparative Pathology, Tulane National Primate Research Center, New Orleans, LA, USA.
  • Rajagopal L; Division of Comparative Pathology, Tulane National Primate Research Center, New Orleans, LA, USA.
  • Hotchkiss CE; Division of Microbiology, Tulane National Primate Research Center, New Orleans, LA, USA.
  • Mohr EL; Division of Veterinary Medicine, Tulane National Primate Research Center, New Orleans, LA, USA.
  • Capuano SV; Division of Veterinary Medicine, Tulane National Primate Research Center, New Orleans, LA, USA.
  • Simmons HA; Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA. adamsk@u.washington.edu.
  • Mejia A; Department of Immunology, University of Washington, Seattle, WA, USA.
  • Friedrich TC; Center for Innate Immunity and Immune Disease, University of Washington, Seattle, WA, USA.
  • Golos TG; Department of Pediatrics, University of Washington, Seattle, WA, USA.
  • O'Connor DH; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA.
Nat Med ; 24(8): 1104-1107, 2018 08.
Article em En | MEDLINE | ID: mdl-29967348
ABSTRACT
Zika virus (ZIKV) infection is associated with congenital defects and pregnancy loss. Here, we found that 26% of nonhuman primates infected with Asian/American ZIKV in early gestation experienced fetal demise later in pregnancy despite showing few clinical signs of infection. Pregnancy loss due to asymptomatic ZIKV infection may therefore be a common but under-recognized adverse outcome related to maternal ZIKV infection.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Aborto Espontâneo / Natimorto / Zika virus / Infecção por Zika virus Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Aborto Espontâneo / Natimorto / Zika virus / Infecção por Zika virus Idioma: En Ano de publicação: 2018 Tipo de documento: Article