Broadband (550-1350 nm) diffuse optical characterization of thyroid chromophores.
Sci Rep
; 8(1): 10015, 2018 07 03.
Article
em En
| MEDLINE
| ID: mdl-29968735
ABSTRACT
Thyroid plays an important role in the endocrine system of the human body. Its characterization by diffuse optics can open new path ways in the non-invasive diagnosis of thyroid pathologies. Yet, the absorption spectra of tyrosine and thyroglobulin-key tissue constituents specific to the thyroid organ-in the visible to near infrared range are not fully available. Here, we present the optical characterization of tyrosine (powder), thyroglobulin (granular form) and iodine (aqueous solution) using a time domain broadband diffuse optical spectrometer in the 550-1350 nm range. Various systematic errors caused by physics of photo migration and sample inherent properties were effectively suppressed by means of advanced time domain diffuse optical methods. A brief comparison with various other known tissue constituents is presented, which reveals key spectral regions for the quantification of the thyroid absorbers in an in vivo scenario.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Análise Espectral
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Tireoglobulina
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Glândula Tireoide
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Tirosina
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Nódulo da Glândula Tireoide
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Iodo
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article