Structural and functional studies of histidine biosynthesis in Acanthamoeba spp. demonstrates a novel molecular arrangement and target for antimicrobials.

Rice, Christopher A; Campbell, Sara J; Bisson, Claudine; Owen, Hayley J; Sedelnikova, Svetlana E; Baker, Patrick J; Rice, David W; Henriquez, Fiona L; Roberts, Craig W

Rice, Christopher A; Campbell, Sara J; Bisson, Claudine; Owen, Hayley J; Sedelnikova, Svetlana E; Baker, Patrick J; Rice, David W; Henriquez, Fiona L; Roberts, Craig W.

Afiliação

Rice CA; Institute of Biomedical and Environmental Health Research, School of Science and Sport, University of West of Scotland, Paisley, United Kingdom.
Campbell SJ; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom.
Bisson C; Institute of Biomedical and Environmental Health Research, School of Science and Sport, University of West of Scotland, Paisley, United Kingdom.
Owen HJ; Department of Molecular Biology and Biotechnology, Krebs Institute for Biomolecular Research, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom.
Sedelnikova SE; Department of Molecular Biology and Biotechnology, Krebs Institute for Biomolecular Research, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom.
Baker PJ; Department of Molecular Biology and Biotechnology, Krebs Institute for Biomolecular Research, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom.
Rice DW; Department of Molecular Biology and Biotechnology, Krebs Institute for Biomolecular Research, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom.
Henriquez FL; Department of Molecular Biology and Biotechnology, Krebs Institute for Biomolecular Research, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom.
Roberts CW; Institute of Biomedical and Environmental Health Research, School of Science and Sport, University of West of Scotland, Paisley, United Kingdom.

PLoS One ; 13(7): e0198827, 2018.

Article em En | MEDLINE | ID: mdl-29969448

Assuntos

Acanthamoeba/enzimologia; Amitrol (Herbicida)/química; Antiprotozoários/química; Histidina/antagonistas & inibidores; Hidroliases/química; Acanthamoeba/efeitos dos fármacos; Acanthamoeba/genética; Acanthamoeba/crescimento & desenvolvimento; Amitrol (Herbicida)/farmacologia; Antiprotozoários/farmacologia; Processos Autotróficos/efeitos dos fármacos; Processos Autotróficos/genética; Sítios de Ligação; Clonagem Molecular; Cristalografia por Raios X; Escherichia coli/genética; Escherichia coli/metabolismo; Expressão Gênica; Vetores Genéticos/química; Vetores Genéticos/metabolismo; Histidina/biossíntese; Hidroliases/antagonistas & inibidores; Hidroliases/genética; Hidroliases/metabolismo; Cinética; Modelos Moleculares; Ligação Proteica; Conformação Proteica em alfa-Hélice; Conformação Proteica em Folha beta; Domínios e Motivos de Interação entre Proteínas; Multimerização Proteica; Proteínas Recombinantes/química; Proteínas Recombinantes/genética; Proteínas Recombinantes/metabolismo; Termodinâmica

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Acanthamoeba / Amitrol (Herbicida) / Histidina / Hidroliases / Antiprotozoários Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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