Quantitation of intact monoclonal antibody in biological samples: comparison of different data processing strategies.

Qiu, Xi; Kang, Lijuan; Case, Martin; Weng, Naidong; Jian, Wenying

Qiu, Xi; Kang, Lijuan; Case, Martin; Weng, Naidong; Jian, Wenying.

Afiliação

Qiu X; Pharmacokinetics, Dynamics & Metabolism (PDM), Janssen Research & Development, Pharmaceutical Companies of Johnson & Johnson, 1400 Mckean Road, Spring House, PA 19477.
Kang L; Pharmacokinetics, Dynamics & Metabolism (PDM), Janssen Research & Development, Pharmaceutical Companies of Johnson & Johnson, 1400 Mckean Road, Spring House, PA 19477.
Case M; Janssen Biotherapeutics, Janssen Research & Development, Pharmaceutical Companies of Johnson & Johnson, 3210 Merryfield Row, San Diego, CA 92121.
Weng N; Pharmacokinetics, Dynamics & Metabolism (PDM), Janssen Research & Development, Pharmaceutical Companies of Johnson & Johnson, 1400 Mckean Road, Spring House, PA 19477.
Jian W; Pharmacokinetics, Dynamics & Metabolism (PDM), Janssen Research & Development, Pharmaceutical Companies of Johnson & Johnson, 1400 Mckean Road, Spring House, PA 19477.

Bioanalysis ; 10(13): 1055-1067, 2018 Jul 01.

Article em En | MEDLINE | ID: mdl-29972323

Assuntos

Anticorpos Monoclonais/análise; Animais; Anticorpos Monoclonais/administração & dosagem; Anticorpos Monoclonais/metabolismo; Cromatografia Líquida; Haplorrinos; Injeções Intravenosas; Espectrometria de Massas

Palavras-chave

LCMS; intact level; protein bioanalysis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Anticorpos Monoclonais Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo

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PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Anticorpos Monoclonais Idioma: En Ano de publicação: 2018 Tipo de documento: Article