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The effects of kisspeptin on ß-cell function, serum metabolites and appetite in humans.
Izzi-Engbeaya, Chioma; Comninos, Alexander N; Clarke, Sophie A; Jomard, Anne; Yang, Lisa; Jones, Sophie; Abbara, Ali; Narayanaswamy, Shakunthala; Eng, Pei Chia; Papadopoulou, Deborah; Prague, Julia K; Bech, Paul; Godsland, Ian F; Bassett, Paul; Sands, Caroline; Camuzeaux, Stephane; Gomez-Romero, Maria; Pearce, Jake T M; Lewis, Matthew R; Holmes, Elaine; Nicholson, Jeremy K; Tan, Tricia; Ratnasabapathy, Risheka; Hu, Ming; Carrat, Gaelle; Piemonti, Lorenzo; Bugliani, Marco; Marchetti, Piero; Johnson, Paul R; Hughes, Stephen J; James Shapiro, A M; Rutter, Guy A; Dhillo, Waljit S.
Afiliação
  • Izzi-Engbeaya C; Section of Endocrinology and Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK.
  • Comninos AN; Section of Endocrinology and Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK.
  • Clarke SA; Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK.
  • Jomard A; Section of Endocrinology and Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK.
  • Yang L; Section of Endocrinology and Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK.
  • Jones S; Section of Endocrinology and Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK.
  • Abbara A; Section of Endocrinology and Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK.
  • Narayanaswamy S; Section of Endocrinology and Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK.
  • Eng PC; Section of Endocrinology and Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK.
  • Papadopoulou D; Section of Endocrinology and Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK.
  • Prague JK; Section of Endocrinology and Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK.
  • Bech P; Section of Endocrinology and Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK.
  • Godsland IF; Section of Endocrinology and Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK.
  • Bassett P; Section of Metabolic Medicine, Department of Medicine, Imperial College London, St Mary's Hospital, London, UK.
  • Sands C; Statsconsultancy Ltd, Amersham, UK.
  • Camuzeaux S; The MRC-NIHR National Phenome Centre and Imperial BRC Clinical Phenotyping Centre, Division of Computational, Systems and Digestive Medicine, Department of Surgery and Cancer, London, UK.
  • Gomez-Romero M; The MRC-NIHR National Phenome Centre and Imperial BRC Clinical Phenotyping Centre, Division of Computational, Systems and Digestive Medicine, Department of Surgery and Cancer, London, UK.
  • Pearce JTM; The MRC-NIHR National Phenome Centre and Imperial BRC Clinical Phenotyping Centre, Division of Computational, Systems and Digestive Medicine, Department of Surgery and Cancer, London, UK.
  • Lewis MR; The MRC-NIHR National Phenome Centre and Imperial BRC Clinical Phenotyping Centre, Division of Computational, Systems and Digestive Medicine, Department of Surgery and Cancer, London, UK.
  • Holmes E; The MRC-NIHR National Phenome Centre and Imperial BRC Clinical Phenotyping Centre, Division of Computational, Systems and Digestive Medicine, Department of Surgery and Cancer, London, UK.
  • Nicholson JK; The MRC-NIHR National Phenome Centre and Imperial BRC Clinical Phenotyping Centre, Division of Computational, Systems and Digestive Medicine, Department of Surgery and Cancer, London, UK.
  • Tan T; The MRC-NIHR National Phenome Centre and Imperial BRC Clinical Phenotyping Centre, Division of Computational, Systems and Digestive Medicine, Department of Surgery and Cancer, London, UK.
  • Ratnasabapathy R; Section of Endocrinology and Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK.
  • Hu M; Section of Endocrinology and Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK.
  • Carrat G; Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK.
  • Piemonti L; Imperial Pancreatic Islet Biology and Diabetes Consortium, Hammersmith Hospital, Imperial College London, London, UK.
  • Bugliani M; Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK.
  • Marchetti P; Imperial Pancreatic Islet Biology and Diabetes Consortium, Hammersmith Hospital, Imperial College London, London, UK.
  • Johnson PR; Diabetes Research Institute (SR-DRI), IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Hughes SJ; Faculty of Medicine, Vita-Salute San Raffaele University, Milan, Italy.
  • James Shapiro AM; Department of Clinical and Experimental Medicine, Islet Cell Laboratory, University of Pisa, Pisa, Italy.
  • Rutter GA; Department of Clinical and Experimental Medicine, Islet Cell Laboratory, University of Pisa, Pisa, Italy.
  • Dhillo WS; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
Diabetes Obes Metab ; 20(12): 2800-2810, 2018 12.
Article em En | MEDLINE | ID: mdl-29974637
ABSTRACT

AIMS:

To investigate the effect of kisspeptin on glucose-stimulated insulin secretion and appetite in humans. MATERIALS AND

METHODS:

In 15 healthy men (age 25.2 ± 1.1 years; BMI 22.3 ± 0.5 kg m-2 ), we compared the effects of 1 nmol kg-1 h-1 kisspeptin versus vehicle administration on glucose-stimulated insulin secretion, metabolites, gut hormones, appetite and food intake. In addition, we assessed the effect of kisspeptin on glucose-stimulated insulin secretion in vitro in human pancreatic islets and a human ß-cell line (EndoC-ßH1 cells).

RESULTS:

Kisspeptin administration to healthy men enhanced insulin secretion following an intravenous glucose load, and modulated serum metabolites. In keeping with this, kisspeptin increased glucose-stimulated insulin secretion from human islets and a human pancreatic cell line in vitro. In addition, kisspeptin administration did not alter gut hormones, appetite or food intake in healthy men.

CONCLUSIONS:

Collectively, these data demonstrate for the first time a beneficial role for kisspeptin in insulin secretion in humans in vivo. This has important implications for our understanding of the links between reproduction and metabolism in humans, as well as for the ongoing translational development of kisspeptin-based therapies for reproductive and potentially metabolic conditions.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Apetite / Células Secretoras de Insulina / Kisspeptinas / Secreção de Insulina Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Apetite / Células Secretoras de Insulina / Kisspeptinas / Secreção de Insulina Idioma: En Ano de publicação: 2018 Tipo de documento: Article