High-yielding 18F radiosynthesis of a novel oxytocin receptor tracer, a probe for nose-to-brain oxytocin uptake in vivo.
Chem Commun (Camb)
; 54(58): 8120-8123, 2018 Jul 17.
Article
em En
| MEDLINE
| ID: mdl-29974895
ABSTRACT
A novel Al18F labelled peptide tracer for PET imaging of oxytocin receptor has been accessed through a high radiochemical yield approach. This tracer showed comparable affinity and higher selectivity and stability compared to oxytocin, and was used to demonstrate direct nose-to-brain uptake following intranasal administration, a common yet controversial delivery route for oxytocin-based therapeutics.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peptídeos Cíclicos
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Encéfalo
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Receptores de Ocitocina
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Compostos Radiofarmacêuticos
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Compostos Heterocíclicos com 1 Anel
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article