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Gene Expression Signature for Prediction of Golimumab Response in a Phase 2a Open-Label Trial of Patients With Ulcerative Colitis.
Telesco, Shannon E; Brodmerkel, Carrie; Zhang, Hongyan; Kim, Lilianne Lee-Lian; Johanns, Jewel; Mazumder, Abhijit; Li, Katherine; Baribaud, Frédéric; Curran, Mark; Strauss, Richard; Paxson, Bethany; Plevy, Scott; Davison, Timothy; Knight, Laura; Dibben, Sian; Schreiber, Stefan; Sandborn, William; Rutgeerts, Paul; Siegel, Corey A; Reinisch, Walter; Greenbaum, Linda E.
Afiliação
  • Telesco SE; Immunology Biomarker, Janssen Research and Development, LLC, Spring House, Pennsylvania. Electronic address: stelesco@its.jnj.com.
  • Brodmerkel C; Immunology Biomarker, Janssen Research and Development, LLC, Spring House, Pennsylvania.
  • Zhang H; Clinical Biostatistics, Janssen Research and Development, LLC, Spring House, Pennsylvania.
  • Kim LL; Clinical Biostatistics, Janssen Research and Development, LLC, Spring House, Pennsylvania.
  • Johanns J; Clinical Biostatistics, Janssen Research and Development, LLC, Spring House, Pennsylvania.
  • Mazumder A; R&D Operations, Janssen Diagnostics, Janssen Research and Development, LLC, Spring House, Pennsylvania (former); Companion Diagnostics, Oncology Biomarker Development, Genentech, South San Francisco, California.
  • Li K; Immunology Biomarker, Janssen Research and Development, LLC, Spring House, Pennsylvania.
  • Baribaud F; Immunology Biomarker, Janssen Research and Development, LLC, Spring House, Pennsylvania.
  • Curran M; Immunology Companion Diagnostics, Janssen Research and Development, LLC, Spring House, Pennsylvania.
  • Strauss R; Translational Medicine Science, Janssen Research and Development, LLC, Spring House, Pennsylvania.
  • Paxson B; Global Regulatory Affairs, Immunology, Janssen Research and Development, LLC, Spring House, Pennsylvania.
  • Plevy S; Disease Area Stronghold, Inflammatory Bowel Diseases, Janssen Research and Development, LLC, Spring House, Pennsylvania.
  • Davison T; Bioinformatics and Biostatistics, Almac Group, Craigavon, United Kingdom.
  • Knight L; Internal Product Development, Almac Group, Craigavon, United Kingdom.
  • Dibben S; Bioinformatics and Biostatistics, Almac Group, Craigavon, United Kingdom.
  • Schreiber S; Institute for Clinical Molecular Biology, Kiel, Germany.
  • Sandborn W; Department of Medicine, University of California San Diego, La Jolla, California.
  • Rutgeerts P; Department of Gastroenterology, University of Leuven, Leuven, Belgium.
  • Siegel CA; The Dartmouth Institute for Health Policy & Clinical Practice, Dartmouth-Hitchcock Inflammatory Bowel Disease Center, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire.
  • Reinisch W; Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
  • Greenbaum LE; Clinical Development, Gastrointestinal, Immunology, Janssen Research and Development, LLC, Spring House, Pennsylvania (former); Novartis Institutes for Biomedical Research, East Hanover, New Jersey.
Gastroenterology ; 155(4): 1008-1011.e8, 2018 10.
Article em En | MEDLINE | ID: mdl-29981298
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fármacos Gastrointestinais / Colite Ulcerativa / Colo / Perfilação da Expressão Gênica / Transcriptoma / Mucosa Intestinal / Anti-Inflamatórios / Anticorpos Monoclonais Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fármacos Gastrointestinais / Colite Ulcerativa / Colo / Perfilação da Expressão Gênica / Transcriptoma / Mucosa Intestinal / Anti-Inflamatórios / Anticorpos Monoclonais Idioma: En Ano de publicação: 2018 Tipo de documento: Article