Synergistic Catalysis: Highly Enantioselective Acetyl Aza-arene Addition to Enals.
Chemistry
; 24(50): 13306-13310, 2018 Sep 06.
Article
em En
| MEDLINE
| ID: mdl-29989264
ABSTRACT
A novel catalytic enantioselective methodology based on synergistic catalysis for the synthesis of chiral 2-acyl pyridines and pyrazines is reported. The strategy involves the metal-Lewis acid activation of acetyl aza-arenes and the secondary-amine activation of enals. The proposed mechanism is supported by DFT calculations.
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MEDLINE
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En
Ano de publicação:
2018
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Article