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Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia.
Dieck, Chelsea L; Tzoneva, Gannie; Forouhar, Farhad; Carpenter, Zachary; Ambesi-Impiombato, Alberto; Sánchez-Martín, Marta; Kirschner-Schwabe, Renate; Lew, Scott; Seetharaman, Jayaraman; Tong, Liang; Ferrando, Adolfo A.
Afiliação
  • Dieck CL; Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA.
  • Tzoneva G; Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA.
  • Forouhar F; Hervert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA; Department of Biological Sciences, Northeast Structural Genomics Consortium, Columbia University, 1212 Amsterdam Avenue, 701 Fairchild Center, New York, NY 10027, USA.
  • Carpenter Z; Department of Systems Biology, Columbia University, New York, NY 10032, USA.
  • Ambesi-Impiombato A; Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA.
  • Sánchez-Martín M; Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA.
  • Kirschner-Schwabe R; Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin 10117, Germany.
  • Lew S; Department of Biological Sciences, Northeast Structural Genomics Consortium, Columbia University, 1212 Amsterdam Avenue, 701 Fairchild Center, New York, NY 10027, USA.
  • Seetharaman J; New York Structural Biology Center, New York, NY 10027, USA.
  • Tong L; Department of Biological Sciences, Northeast Structural Genomics Consortium, Columbia University, 1212 Amsterdam Avenue, 701 Fairchild Center, New York, NY 10027, USA. Electronic address: ltong@columbia.edu.
  • Ferrando AA; Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA; Department of Systems Biology, Columbia University, New York, NY 10032, USA; Department of Pediatrics, Columbia University Medical Center, 1130 St. Nicholas Avenue, ICRC 402, New York, NY 10032, USA; Department of Pathology
Cancer Cell ; 34(1): 136-147.e6, 2018 07 09.
Article em En | MEDLINE | ID: mdl-29990496
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: 5'-Nucleotidase / Resistencia a Medicamentos Antineoplásicos / Leucemia-Linfoma Linfoblástico de Células Precursoras / Mercaptopurina / Mutação / Antimetabólitos Antineoplásicos Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: 5'-Nucleotidase / Resistencia a Medicamentos Antineoplásicos / Leucemia-Linfoma Linfoblástico de Células Precursoras / Mercaptopurina / Mutação / Antimetabólitos Antineoplásicos Idioma: En Ano de publicação: 2018 Tipo de documento: Article