A protonic biotransducer controlling mitochondrial ATP synthesis.
Sci Rep
; 8(1): 10423, 2018 Jul 12.
Article
em En
| MEDLINE
| ID: mdl-30002478
ABSTRACT
In nature, protons (H+) play an important role in biological activities such as in mitochondrial ATP synthesis, which is driven by a H+ gradient across the inner membrane, or in the activation of acid sensing ion channels in neuron cells. Bioprotonic devices directly interface with the H+ concentration (pH) to facilitate engineered interactions with these biochemical processes. Here we develop a H+ biotransducer that changes the pH in a mitochondrial matrix by controlling the flow of H+ between a conductive polymer of sulfonated polyaniline and solution. We have successfully modulated the rate of ATP synthesis in mitochondria by altering the solution pH. Our H+ biotransducer provides a new way to monitor and modulate pH dependent biological functions at the interface between the electronic devices and biological materials.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Prótons
/
Transdutores
/
Trifosfato de Adenosina
/
Bioengenharia
/
Mitocôndrias
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article