Nitro-fatty acid formation and metabolism.
Nitric Oxide
; 79: 38-44, 2018 09 01.
Article
em En
| MEDLINE
| ID: mdl-30006146
ABSTRACT
Nitro-fatty acids (NO2-FA) are pleiotropic modulators of redox signaling pathways. Their effects on inflammatory signaling have been studied in great detail in cell, animal and clinical models primarily using exogenously administered nitro-oleic acid. While we know a considerable amount regarding NO2-FA signaling, endogenous formation and metabolism is relatively unexplored. This review will cover what is currently known regarding the proposed mechanisms of NO2-FA formation, dietary modulation of endogenous NO2-FA levels, pathways of NO2-FA metabolism and the detection of NO2-FA and corresponding metabolites.
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Base de dados:
MEDLINE
Assunto principal:
Ácidos Graxos
/
Nitrocompostos
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article