Bone Disease in Mastocytosis.
Immunol Allergy Clin North Am
; 38(3): 443-454, 2018 08.
Article
em En
| MEDLINE
| ID: mdl-30007462
ABSTRACT
Systemic mastocytosis can give very different bone pictures from osteosclerosis to osteoporosis. Osteoporosis is one of the most frequent manifestations particularly in adults and the most clinical relevant. It is often complicated by a high recurrence of mainly vertebral fragility fractures. The main factor of bone loss is the osteoclast with a relative or absolute predominance of bone resorption. The RANK-RANKL pathway seems of key importance, but histamine and other cytokines also play a significant role in the process. The predominance of resorption made bisphosphonates, as anti-resorptive drugs, the most rational treatment of bone involvement in systemic mastocytosis.
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Base de dados:
MEDLINE
Assunto principal:
Osteoclastos
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Doenças Ósseas
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Mastocitose Sistêmica
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article