The TRPM2 channel nexus from oxidative damage to Alzheimer's pathologies: An emerging novel intervention target for age-related dementia.
Ageing Res Rev
; 47: 67-79, 2018 Nov.
Article
em En
| MEDLINE
| ID: mdl-30009973
ABSTRACT
Alzheimer's disease (AD), an age-related neurodegenerative condition, is the most common cause of dementia among the elder people, but currently there is no treatment. A number of putative pathogenic events, particularly amyloid ß peptide (Aß) accumulation, are believed to be early triggers that initiate AD. However, thus far targeting Aß generation/aggregation as the mainstay strategy of drug development has not led to effective AD-modifying therapeutics. Oxidative damage is a conspicuous feature of AD, but this remains poorly defined phenomenon and mechanistically ill understood. The TRPM2 channel has emerged as a potentially ubiquitous molecular mechanism mediating oxidative damage and thus plays a vital role in the pathogenesis and progression of diverse neurodegenerative diseases. This article will review the emerging evidence from recent studies and propose a novel 'hypothesis' that multiple TRPM2-mediated cellular and molecular mechanisms cascade Aß and/or oxidative damage to AD pathologies. The 'hypothesis' based on these new findings discusses the prospect of considering the TRPM2 channel as a novel therapeutic target for intervening AD and age-related dementia.
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MEDLINE
Assunto principal:
Envelhecimento
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Estresse Oxidativo
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Canais de Cátion TRPM
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Doença de Alzheimer
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article