Kaempferol inhibits interleukin­1ß stimulated matrix metalloproteinases by suppressing the MAPK­associated ERK and P38 signaling pathways.

Huang, Xiaojian; Pan, Qiyong; Mao, Zekai; Wang, Pengcheng; Zhang, Rui; Ma, Xiaohu; Chen, Jingyuan; You, Hongbo

Kaempferol inhibits interleukin1ß stimulated matrix metalloproteinases by suppressing the MAPKassociated ERK and P38 signaling pathways.

Huang, Xiaojian; Pan, Qiyong; Mao, Zekai; Wang, Pengcheng; Zhang, Rui; Ma, Xiaohu; Chen, Jingyuan; You, Hongbo.

Afiliação

Huang X; Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China.
Pan Q; Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China.
Mao Z; Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China.
Wang P; Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China.
Zhang R; Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China.
Ma X; Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China.
Chen J; Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China.
You H; Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China.

Mol Med Rep ; 18(3): 2697-2704, 2018 Sep.

Article em En | MEDLINE | ID: mdl-30015923

Assuntos

Interleucina-1beta/farmacologia; Quempferóis/farmacologia; Sistema de Sinalização das MAP Quinases/efeitos dos fármacos; Metaloproteinase 13 da Matriz/metabolismo; Metaloproteinase 1 da Matriz/metabolismo; Metaloproteinase 3 da Matriz/metabolismo; Proteína ADAMTS5/genética; Proteína ADAMTS5/metabolismo; Animais; Condrócitos/citologia; Condrócitos/efeitos dos fármacos; Condrócitos/metabolismo; Ciclo-Oxigenase 2/genética; Ciclo-Oxigenase 2/metabolismo; MAP Quinases Reguladas por Sinal Extracelular/metabolismo; Expressão Gênica/efeitos dos fármacos; Metaloproteinase 1 da Matriz/genética; Metaloproteinase 13 da Matriz/genética; Metaloproteinase 3 da Matriz/genética; Óxido Nítrico Sintase Tipo II/genética; Óxido Nítrico Sintase Tipo II/metabolismo; Ratos; Ratos Sprague-Dawley; Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Metaloproteinase 3 da Matriz / Metaloproteinase 1 da Matriz / Sistema de Sinalização das MAP Quinases / Quempferóis / Metaloproteinase 13 da Matriz / Interleucina-1beta Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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