The Neuroplastic and Therapeutic Potential of Spinal Interneurons in the Injured Spinal Cord.
Trends Neurosci
; 41(9): 625-639, 2018 09.
Article
em En
| MEDLINE
| ID: mdl-30017476
ABSTRACT
The central nervous system is not a static, hard-wired organ. Examples of neuroplasticity, whether at the level of the synapse, the cell, or within and between circuits, can be found during development, throughout the progression of disease, or after injury. One essential component of the molecular, anatomical, and functional changes associated with neuroplasticity is the spinal interneuron (SpIN). Here, we draw on recent multidisciplinary studies to identify and interrogate subsets of SpINs and their roles in locomotor and respiratory circuits. We highlight some of the recent progress that elucidates the importance of SpINs in circuits affected by spinal cord injury (SCI), especially those within respiratory networks; we also discuss potential ways that spinal neuroplasticity can be therapeutically harnessed for recovery.
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Base de dados:
MEDLINE
Assunto principal:
Sistema Respiratório
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Medula Espinal
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Traumatismos da Medula Espinal
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Interneurônios
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Plasticidade Neuronal
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article