Cleft Alveolus Reconstruction Using a Three-Dimensional Printed Bioresorbable Scaffold With Human Bone Marrow Cells.
J Craniofac Surg
; 29(7): 1880-1883, 2018 Oct.
Article
em En
| MEDLINE
| ID: mdl-30028404
ABSTRACT
Bone tissue engineering technology based on scaffold has been applied for cleft lip and palate treatment. However, clinical applications of patient-specific three-dimensional (3D) scaffolds have rarely been performed. In this study, a clinical case using patient-specific 3D-printed bioresorbable scaffold with bone marrow stromal cells collected from iliac crest in the operating room has been introduced. At 6-month after transplantation, the bone volume of the newly regenerated bone was approximately 45% of the total defect volume. Bone mineral density of the newly regenerated bone was about 75% compared to the surrounding bone. The Hounsfield unit value was higher than that of cancellous maxillary alveolar bone and lower than that of the cortical maxillary alveolar bone. Bone-marrow-derived mesenchymal stem cells-seeded 3D-printed patient-specific polycaprolactone scaffolds offer a promising alternative for alveolar cleft reconstruction and other bony defects.
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Base de dados:
MEDLINE
Assunto principal:
Implantes Absorvíveis
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Transplante de Células-Tronco Mesenquimais
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Alicerces Teciduais
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Processo Alveolar
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article